Results 51 to 60 of about 247,513 (260)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

QTLMAS 2009: simulated dataset [PDF]

, 2010
Background - The simulation of the data for the QTLMAS 2009 Workshop is described. Objective was to simulate observations from a growth curve which was influenced by a number of QTL.
Coster, A., Albart Coster, Bastiaansen, J.W.M., Bink, M.C.A.M., Chris Maliepaard, Mario Calus, Calus, M.P.L., John Bastiaansen, Marco C A M Bink, John W M Bastiaansen, Marco Bink, Mario P L Calus, Maliepaard, C.A.   +12 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Trait-Based Ecology of Terrestrial Arthropods

, 2019
***After downloading, open in PowerPoint, click "Slide Show" >> "Play from Start", and narration will run automatically***Trait-Based Ecology of Terrestrial ArthropodsA speed-presentation (8 mins) by Mark Wong (University of Oxford) at the Unpicking the ...
Mark Wong (7331033)
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Functional trait measurement methodology.

, 2023
1. Though not often examined together, both plant-soil feedbacks (PSFs) and functional traits have important influences on plant community dynamics and could interact.
Richard K. Kobe (2914160), Inés Ibáñez (2905388), Sarah McCarthy-Neumann (2916119), Katherine E. A. Wood (17325907)   +3 more
core   +1 more source

Secondary production and biomass in mussel assemblages relate to species richness and stream size but not life history

Ecosphere
Increases in species richness with habitat area (species–area relationship, or SAR) and increases in ecosystem function with species richness (biodiversity–ecosystem functioning, or BEF) are widely studied ecological patterns.
Jonathan W. Lopez, Carla L. Atkinson, Angela K. Burrow, Garrett W. Hopper, Wendell R. Haag   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Intraspecific trait changes have large impacts on community functional composition but do not affect ecosystem function [PDF]

, 2021
Plant functional traits can provide a mechanistic understanding of community responses to global change and of community effects on ecosystem functions.
Pichon, N. A. (Noémie A.), Pichon, Noémie A., Noémie A. Pichon, Allan, E. (Eric), Allan, Eric, Cappelli, S. L. (Seraina L.), Eric Allan, Cappelli, Seraina L., Seraina L. Cappelli   +8 more
core   +1 more source