Results 61 to 70 of about 888,994 (304)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

TRY plant trait database - enhanced coverage and open access [PDF]

open access: yes, 2020
Plant traits-the morphological, anatomical, physiological, biochemical and phenological characteristics of plants-determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits ...
Aakala, T   +727 more
core  

Applying trait-based models to achieve functional targets for theory-driven ecological restoration [PDF]

open access: yes, 2014
Manipulating community assemblages to achieve functional targets is a key component of restoring degraded ecosystems. The response-and-effect trait framework provides a conceptual foundation for translating restoration goals into functional trait targets,
Laughlin, Daniel C.
core   +2 more sources

Functional traits of fossil plants

open access: yesNew Phytologist
SummaryA minuscule fraction of the Earth's paleobiological diversity is preserved in the geological record as fossils. What plant remnants have withstood taphonomic filtering, fragmentation, and alteration in their journey to become part of the fossil record provide unique information on how plants functioned in paleo‐ecosystems through their traits ...
McElwain, Jennifer C.   +14 more
openaire   +3 more sources

Geographic patterns and drivers of leaf functional traits in mangrove forests across Hainan Island: Climate dominance and context-dependent mechanisms

open access: yesGlobal Ecology and Conservation
Disentangling the responses of leaf functional traits to global environmental changes is crucial for understanding biodiversity-ecosystem functioning (BEF) linkages.
Jingyi Cui   +7 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

Response of functional traits of Castanopsis hystrix leaves to geographical environment factors

open access: yesGuangxi Zhiwu
Leaf is an important nutrient organ for physiological and biochemical activities of plants, and its functional traits reflect the environmental adaptability of plants to a certain extent.
LI Qiguo 1, JIANG Weixin1, TAN Zhangqiang2, BAI Tiandao1*, SHEN Wenhui2
doaj   +1 more source

Single Grazing Is More Detrimental to Grasslands Than Mixed Grazing: Evidence From the Response of Functional Traits of Dominant Plants to Grazing Systems

open access: yesFrontiers in Ecology and Evolution, 2021
Plant functional traits reflect species ecological strategies and determine how plants respond to environmental changes, however, how dominant species in the Inner Mongolia grassland adapt to different grazing systems by changing their functional traits ...
Zheng Wang   +9 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era. [PDF]

open access: yes, 2019
The horse reference genome from the Thoroughbred mare Twilight has been available for a decade and, together with advances in genomics technologies, has led to unparalleled developments in equine genomics.
Bellone, R   +3 more
core   +2 more sources

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