Results 81 to 90 of about 845,849 (268)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The analysis of the method on the one variable function’s limit [PDF]

Proceedings of the 2015 International Conference on Advances in Mechanical Engineering and Industrial Informatics, 2015
The limit of one variable function is an important problem in Higher Mathematics, it is a basic method to study the relationship between the function of variables. This template describes some important method about counting the limit, and gives the solving skills.
openaire   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Blowup and Global Solutions of a Fourth-Order Parabolic Equation With Variable Exponent Logarithmic Nonlinearity

Journal of Function Spaces
In this work, we deal with a fourth-order parabolic equation with variable exponent logarithmic nonlinearity. We obtain the global existence and blowup solutions using the energy functional and potential well method.
Gülistan Butakın, Erhan Pişkin, Ercan Çelik   +2 more
doaj   +1 more source

Fixed Point Theory and the Ulam Stability

Journal of Function Spaces, 2014
The fixed point method has been applied for the first time, in proving the stability results for functional equations, by Baker (1991); he used a variant of Banach's fixed point theorem to obtain the stability of a functional equation in a single ...
Janusz Brzdęk, Liviu Cădariu, Krzysztof Ciepliński   +2 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Inclusion methods for real and complex functions in one variable.

RITA, 1995
A new method is discussed for obtaining a validated inclusion of a zero of a real or complex function in one variable. The method is given by means of a sufficient criterion which can be tested on a digital computer. The numeral results show that, compared to other methods, the new one frequently yields very narrow bounds for the solution.
Claudio, Dalcidio Moraes, Rump, Siegfried M.   +1 more
openaire   +2 more sources

Splitting methods with variable metric for KL functions

, 2014
We study the convergence of general abstract descent methods applied to a lower semicontinuous nonconvex function f that satisfies the Kurdyka-Lojasiewicz inequality in a Hilbert space. We prove that any precompact sequence converges to a critical point of f and obtain new convergence rates both for the values and the iterates.
Frankel, Pierre, Garrigos, Guillaume, Peypouquet, Juan   +2 more
openaire   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source