Results 61 to 70 of about 845,849 (268)

Vertex method for computing functions of fuzzy variables

Fuzzy Sets and Systems, 1987
The calculation of (fuzzy) values of functions of fuzzy variables is considered. A so-called vertex method is proposed which is based on interval analysis, discretization, extension principle and alfa-cuts of the respective fuzzy sets. The method is easily implementable, and yields normal fuzzy sets, without widening of the resulting function value set.
Dong, Weimin, Shah, Haresh C.
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Practical Stability with Respect to h-Manifolds for Impulsive Control Functional Differential Equations with Variable Impulsive Perturbations

Mathematics, 2019
The present paper is devoted to the problems of practical stability with respect to h-manifolds for impulsive control differential equations with variable impulsive perturbations.
Gani Stamov, Ivanka Stamova, Xiaodi Li, Ekaterina Gospodinova   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A new concept of q-calculus with respect to another function

Journal of Innovative Applied Mathematics and Computational Sciences
In this paper, we present an approach to quantum calculus and its applications through a functional method. This approach enables the exploration of the number-theoretic properties of q-calculus in a functional framework, facilitating the modification ...
Shrinath Manjarekar, Hossein Jafari
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Large Displacement Analysis of Toroidal Dome Structures Having Variable Thickness under External Pressure

RMUTL Engineering Journal
This paper presents a large displacement analysis of a toroidal dome structure having variable thickness under external pressure using differential geometry.
Weeraphan Jiammeepreecha, Satakhun Detphan, Komkorn Chaidachatorn, Chanchai Ngohpok, Sermsak Tiyasangthong, Chudapak Detphan, Korakot Lerdchaipong, Sittisak Jamnam   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source