Results 201 to 210 of about 934,400 (317)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Empirical evaluation of all unique Cas9 protospacers in E. coli reveal widespread functionality and rules for gRNA design. [PDF]

Nucleic Acids Res
Kammerdiener EK, Hren AP, Harrison R, Charles S, Klingeman D, Wiser TD, Eckert CA, Alexander WG.   +7 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Module 1 functionality in planning and land development, Module 2a operational functionality, Module 2b operational functionality, Module 3 right of way and functionality, Module 4 safety and functionality

Workshop Objectives:\u2022 To promote the importance of Highway Functionality\u2022 To review functionality in highway lifecycle\u2022 To provide \u2018how to\u2019 materials to preserve, maintain, and enhance functionality\u2022 To promote coordination ...
Hard, Edwin N., Bochner, Brian S., Texas Transportation Institute   +2 more
core  

Impact of a Functional Intervention with Home Follow-Up on Respiratory Symptoms and Functionality in Oncology Patients: A Randomised Clinical Trial. [PDF]

Support Care Cancer
Fernandez-Rodriguez EJ, Sanchez-Gomez C, Fonseca-Sanchez E, Rihuete-Galve MI, Hernández JJC.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Module 2b operational functionality, Module 3 right of way and functionality, Module 4 safety and functionality

Workshop Objectives: \u2022 To promote the importance of Highway Functionality \u2022 To review functionality in highway lifecycle \u2022 To provide \u2018how to\u2019 materials to preserve, maintain, and enhance functionality \u2022 To promote ...
Hard, Edwin N., Bochner, Brian S., Texas Transportation Institute   +2 more
core  

Hospital functionality in the Gaza Strip: analysis of the World Health Organization health resources and services availability monitoring system database, 7 Oct 2023 to 31 Oct 2024. [PDF]

Confl Health
Mills D, Asi Y, Kunichoff D, Nelson E, Nasser J, Barkley S, Arias Delafosse R, Scher C, Tanous O, Hammoudeh W, Wispelwey B, Bahour N, Peeperkorn R, Evers E, Gonsalves L, Van Den Hoek J, Greenough PG.   +16 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

High Density Lipoprotein Assessment Revisited: A Review of Foundational Understanding and Recent Developments in Function, Particle Size, and Cardiometabolic Impact. [PDF]

Curr Atheroscler Rep
Sherly A A, Mysore Srikantiah R, Rohatgi A, Hegde A, H S, S A.   +5 more
europepmc   +1 more source