Results 101 to 110 of about 120,410 (255)

Numerical simulation of elastic wave propagation in functionally graded cylinders using time-domain spectral finite element method

Advances in Mechanical Engineering, 2017
Functionally graded material is a new class of composite materials with gradually varying material contents. In this article, a two-dimensional axisymmetric time-domain spectral finite element method is proposed for the analysis of elastic wave ...
Chao Xu, Zexing Yu
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Modeling and Evaluation of Vibrational Behavior in Functionally Graded Ceramic-Metal Composite Beams

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
Functionally Graded Materials (FGMs) represent a notable advancement in materials research as they enable the smooth incorporation of distinct characteristics from various materials.
Ziadoon Mohammed Rahi, Hayder H. Khaleel
doaj   +1 more source

Effective conductivity of composites of graded spherical particles

, 2005
We have employed the first-principles approach to compute the effective response of composites of graded spherical particles of arbitrary conductivity profiles. We solve the boundary-value problem for the polarizability of the graded particles and obtain
Arnold, Bollenbach, Chan, Dong, Dong, Fuhr, G.Q. Gu, Gu, Gu, Gu, Holt, Huang, Huang, Hughes, Ilschner, Jackson, K.W. Yu, Larson, Lin, Martin, Milton, Snyder, Wei, Yu, Yu   +24 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Microstructure and mechanical properties of Ti60–Ti2AlNb functionally graded materials fabricated by laser directed energy deposition

Journal of Materials Research and Technology
The increasing demands for materials that service under high temperature environments in advanced aero-engines with high thrust-to-weight ratios have led to the exploration of functionally graded materials, which can offer unique advantages for ...
Yaguang Wang, Shuai Liu, Yasong Tan, Meng Wang, Shufan Xian, Xueping Li, Qian Wang, Jiabao Guo, Xin Lin, Weidong Huang   +9 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Transference of shear horizontal waves in a functionally graded piezoelectric structure

Partial Differential Equations in Applied Mathematics
A brief analysis of the transference of shear horizontal wave has been carried out in a functionally graded half-spaces bonded imperfectly. The top half-space is functionally graded piezoelectric material whereas the bottom half-space is elastic ...
A. Akshaya, S. Kumar, K. Prasad, D. Majhi   +3 more
doaj   +1 more source

Dispersive waves in functionally graded plates

MATEC Web of Conferences, 2018
The dispersion waves propagating in anisotropic functionally graded (FG) plates with arbitrary transverse heterogeneity and arbitrary elastic monoclinic anisotropy are analysed within a recently developed six-dimensional formalism.
Ilyashenko Alla, Kuznetsov Sergey
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source