Results 91 to 100 of about 368,543 (249)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Delamination Fracture Analyses of Linear-Elastic Functionally Graded Beams

Engineering Transactions, 2017
An analytical approach for investigation of delamination cracks in three-dimensional functionally graded linear-elastic beams was developed. Beams which are functionally graded along their width, height and length were analyzed.
Victor Iliev RIZOV
doaj   +1 more source

Development of Strong Surfaces Using Functionally Graded Composites Inspired by Natural Teeth—A Theoretical Approach

, 2010
In recent years functionally-graded composites have been proposed to develop strong surfaces that can withstand high contact and frictional forces. The present work presents a new graded composite that can be used for the development of surfaces with ...
Kordolemis, A., Zisis, T., Zisis, T, Kordolemis, A, Giannakopoulos, A, Zisis, Th., Giannakopoulos, A. E.   +6 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mechanical Modeling of Thin Films Bonded To Functionally Graded Materials

, 2010
In this study the contact problems of thin films bonded to Functionally Graded Materials (FGM) are considered. In these problems the loading consists of any one or combination of stresses caused by uniform temperature changes and temperature excursions ...
Dağ, Serkan, Gülver, Yusuf Fuat, Güler, Mehmet Ali   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Fracture mechanical modelling and damage characterization of functionally graded thermal barrier coatings by means of laser irradiation

, 2022
S.450-456The fracture and damage behaviour of high temperature materials can be modified by realizing well-defined property gradients. The damage characterization of thermal barrier coatings (TBCs) by means of laser irradiation shows that crack ...
Balke, H., Häusler, C., Bahr, H.-A., Kirchhoff, G., Hofinger, I., Weiss, H.-J.   +5 more
core   +1 more source

Analysis of a heterogeneous functionally graded material with a spherical void exposed to time-dependent ramp-type heating according to the TPL heat conduction model

Scientific Reports
Functionally graded materials (FGMs) are sophisticated composites distinguished by a progressive alteration in composition and characteristics, facilitating customized performance for particular applications.
Sami F. Megahid
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source