Results 71 to 80 of about 121,679 (298)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effects of thickness stretching in functionally graded plates and shells

, 2011
1The present work evaluates the effect of thickness stretching in plate/shell structures made by materials which are functionally graded (FGM) in the thickness directions.
Batra, Bayat, Birman, Brischetto, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Cauchy, Chi, Chi, Chiba, Estili, Ferreira, Haddadpour, Kashtalyan, Kashtalyan, Kirchhoff, Koizumi, Koizumi, Mindlin, Mori, Na, Pagano, Pagano, Pan, Poisson, Qian, Ramirez, Reissner, Vel, Vel, Zenkour   +37 more
core   +1 more source

Grading Diastolic Left Ventricular Function [PDF]

European Journal of Heart Failure, 2011
This editorial refers to ‘Diagnosis of heart failure with pre-served ejection fraction: which parameters and diagnosticstrategies are more valuable?’, by X.-X. Shuai et al.,published in this issue on page 737–745.The diagnosis of heart failure (HF) is based on symptoms and signsof HF, as well as evidence for a functional or structural abnormalityof the
Hummel, Yoran M., Voors, Adriaan A.
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microstructure-based modeling of elastic functionally graded materials: One dimensional case

, 2008
Functionally graded materials (FGMs) are two-phase composites with continuously changing microstructure adapted to performance requirements. Traditionally, the overall behavior of FGMs has been determined using local averaging techniques or a given ...
Beran, Ching, Duddeck, Jan Zeman, Milton, Murat, Neubrand, Rektorys, Zahra Sharif-Khodaei   +8 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Behaviour of functionally graded reinforced-concrete beams under cyclic loading

Građevinar, 2015
Over the past decade, the functional grading has been applied as a new method for the manufacturing of reinforced-concrete elements. The objective of this investigation is to evaluate performance of the functionally graded reinforced-concrete beams ...
Maysam Ghasemi Naghibdehi, Morteza Naghipour, Mahmood Rabiee   +2 more
doaj   +1 more source