Results 101 to 110 of about 368,543 (249)

Modeling and Evaluation of Vibrational Behavior in Functionally Graded Ceramic-Metal Composite Beams

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
Functionally Graded Materials (FGMs) represent a notable advancement in materials research as they enable the smooth incorporation of distinct characteristics from various materials.
Ziadoon Mohammed Rahi, Hayder H. Khaleel
doaj   +1 more source

Free Vibration of Functionally Graded Epoxy/Clay Nanocomposite Beams based on the First Order Shear Deformation Theory [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2019
This paper deals with free vibration of epoxy/clay nanocomposite beams for functionally graded and uniformly distributed of Nanoclay with simply supported conditions at both ends.
Mahdi Karami Khorramabadi
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Transference of shear horizontal waves in a functionally graded piezoelectric structure

Partial Differential Equations in Applied Mathematics
A brief analysis of the transference of shear horizontal wave has been carried out in a functionally graded half-spaces bonded imperfectly. The top half-space is functionally graded piezoelectric material whereas the bottom half-space is elastic ...
A. Akshaya, S. Kumar, K. Prasad, D. Majhi   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Microstructure and mechanical properties of Ti60–Ti2AlNb functionally graded materials fabricated by laser directed energy deposition

Journal of Materials Research and Technology
The increasing demands for materials that service under high temperature environments in advanced aero-engines with high thrust-to-weight ratios have led to the exploration of functionally graded materials, which can offer unique advantages for ...
Yaguang Wang, Shuai Liu, Yasong Tan, Meng Wang, Shufan Xian, Xueping Li, Qian Wang, Jiabao Guo, Xin Lin, Weidong Huang   +9 more
doaj   +1 more source

Numerical simulation of elastic wave propagation in functionally graded cylinders using time-domain spectral finite element method

Advances in Mechanical Engineering, 2017
Functionally graded material is a new class of composite materials with gradually varying material contents. In this article, a two-dimensional axisymmetric time-domain spectral finite element method is proposed for the analysis of elastic wave ...
Chao Xu, Zexing Yu
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Stress intensity factors for functionally graded solid cylinders

, 1999
This paper presents the mode I stress intensity factors for functionally graded solid cylinders with an embedded penny-shaped crack or an external circumferential crack. The solid cylinders are assumed under remote uniform tension.
李春雨, Li, CY (reprint author), Shijiazhuang Railway Inst, Shijiazhuang 050043, Peoples R China., 段祝平, 邹振祝   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source