Results 101 to 110 of about 121,679 (298)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Dispersive waves in functionally graded plates

MATEC Web of Conferences, 2018
The dispersion waves propagating in anisotropic functionally graded (FG) plates with arbitrary transverse heterogeneity and arbitrary elastic monoclinic anisotropy are analysed within a recently developed six-dimensional formalism.
Ilyashenko Alla, Kuznetsov Sergey
doaj   +1 more source

Bending and vibration of functionally graded material sandwich plates using an accurate theory

, 2012
In this paper, the bending and the free flexural vibration behaviour of sandwich functionally graded material (FGM) plates are investigated using QUAD-8 shear flexible element developed based on higher order structural theory.
Ali, Anderson, Bhangale, Das, Ferreira, Ganapathi, Ganapathi Manickam, Koizumi, Li, Makhecha, Murukami, Natarajan, Nosier, Pan, Reddy, Roderigues, S. Natarajan, Shen, Singh, Vel, Zenkour, Zenkour   +21 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Modeling and Evaluation of Vibrational Behavior in Functionally Graded Ceramic-Metal Composite Beams

Mağallaẗ Al-kūfaẗ Al-handasiyyaẗ
Functionally Graded Materials (FGMs) represent a notable advancement in materials research as they enable the smooth incorporation of distinct characteristics from various materials.
Ziadoon Mohammed Rahi, Hayder H. Khaleel
doaj   +1 more source

Free Vibration of Functionally Graded Epoxy/Clay Nanocomposite Beams based on the First Order Shear Deformation Theory [PDF]

International Journal of Advanced Design and Manufacturing Technology, 2019
This paper deals with free vibration of epoxy/clay nanocomposite beams for functionally graded and uniformly distributed of Nanoclay with simply supported conditions at both ends.
Mahdi Karami Khorramabadi
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Transference of shear horizontal waves in a functionally graded piezoelectric structure

Partial Differential Equations in Applied Mathematics
A brief analysis of the transference of shear horizontal wave has been carried out in a functionally graded half-spaces bonded imperfectly. The top half-space is functionally graded piezoelectric material whereas the bottom half-space is elastic ...
A. Akshaya, S. Kumar, K. Prasad, D. Majhi   +3 more
doaj   +1 more source

Numerical simulation of elastic wave propagation in functionally graded cylinders using time-domain spectral finite element method

Advances in Mechanical Engineering, 2017
Functionally graded material is a new class of composite materials with gradually varying material contents. In this article, a two-dimensional axisymmetric time-domain spectral finite element method is proposed for the analysis of elastic wave ...
Chao Xu, Zexing Yu
doaj   +1 more source