Results 91 to 100 of about 75,347 (300)

Effects of thickness stretching in functionally graded plates and shells

, 2011
1The present work evaluates the effect of thickness stretching in plate/shell structures made by materials which are functionally graded (FGM) in the thickness directions.
Batra, Bayat, Birman, Brischetto, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Cauchy, Chi, Chi, Chiba, Estili, Ferreira, Haddadpour, Kashtalyan, Kashtalyan, Kirchhoff, Koizumi, Koizumi, Mindlin, Mori, Na, Pagano, Pagano, Pan, Poisson, Qian, Ramirez, Reissner, Vel, Vel, Zenkour   +37 more
core   +1 more source

Navier Solution for Buckling Analysis of Size-Dependent Functionally Graded Micro-Plates

Latin American Journal of Solids and Structures
In the present paper, buckling analysis of functionally graded rectangular micro-plates, on the basis of strain gradient theory with one length scale parameter is studied.
H. Farahmand, S. S. Naseralavi, A. Iranmanesh, M. Mohammadi   +3 more
doaj   +1 more source

Study on Harmonic Analysis of Functionally Graded Plates Using Fem

International Journal of Applied Mechanics and Engineering, 2018
This paper presents the harmonic and vibration analysis of functionally graded plates using the finite element method. Initially, the plates are assumed isotropic and the material properties of it are assumed to vary continuously through their thickness ...
A.K. Sharma, P. Sharma, P.S. Chauhan, S.S. Bhadoria   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A parametric study on the buckling of functionally graded material plates with internal discontinuities using the partition of unity method

, 2013
In this paper, the effect of local defects, viz., cracks and cutouts on the buckling behaviour of functionally graded material plates subjected to mechanical and thermal load is numerically studied.
Chakraborty, S, Ganapathi, M, Natarajan, S, Subramaniam, M   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Material parameter identification in functionally graded structures using isoparametric graded finite element model

Science and Engineering of Composite Materials, 2016
An identification algorithm based on an isoparametric graded finite element model is developed to identify the material parameters of the plane structure of functionally graded materials (FGMs). The material parameter identification problem is formulated
Huang Lixin, Yang Ming, Zhou Xiaojun, Yao Qi, Wang Lin   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Non-linear buckling analysis of functionally graded shallow spherical shells

Vietnam Journal of Mechanics, 2009
In the present paper the non-linear buckling analysis of functionally graded spherical shells subjected to external pressure is investigated. The material properties are graded in the thickness direction according to the power-law distribution in terms ...
Dao Huy Bich
doaj   +1 more source