Results 71 to 80 of about 5,798,177 (248)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel higher-order trigonometric shear deformation theory for static analysis of porous functionally graded skew plates

Next Materials
This study investigates the bending behavior of skew functionally graded material plates to evaluate the influence of skew angle on structural rigidity. This work distinguishes itself by analyzing how varying skew angles influence the bending rigidity of
Youssef Bouchaouata, Saad Hassouna, Abdelaziz Timesli   +2 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Constitutive modelling and mechanical characterization of aluminium-based metal matrix composites produced by spark plasma sintering [PDF]

, 2010
Spark plasma sintering has been applied to the production of aluminium-based functionally graded material systems to be used in abrasive and high temperature conditions.
Estournès, Claude, C. Estournes, Bolzon, Gabriella, Egizabal, Pedro, E. J. Chiarullo, Chiarullo, Enzo J., P. Egizabal   +6 more
core   +1 more source

Stress concentration analysis in functionally graded plates with elliptic holes under biaxial

Ain Shams Engineering Journal, 2014
Stress concentration factors (SCFs) at the root of an elliptic hole in unidirectional functionally graded material (UDFGM) plates under uniaxial and biaxial loads are predicted. ANSYS Parametric Design Language (APDL) was used to build the finite element
Tawakol A. Enab
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Navier Solution for Buckling Analysis of Size-Dependent Functionally Graded Micro-Plates

Latin American Journal of Solids and Structures
In the present paper, buckling analysis of functionally graded rectangular micro-plates, on the basis of strain gradient theory with one length scale parameter is studied.
H. Farahmand, S. S. Naseralavi, A. Iranmanesh, M. Mohammadi   +3 more
doaj   +1 more source

Material parameter identification in functionally graded structures using isoparametric graded finite element model

Science and Engineering of Composite Materials, 2016
An identification algorithm based on an isoparametric graded finite element model is developed to identify the material parameters of the plane structure of functionally graded materials (FGMs). The material parameter identification problem is formulated
Huang Lixin, Yang Ming, Zhou Xiaojun, Yao Qi, Wang Lin   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source