Results 71 to 80 of about 20,756 (262)

Use of Functionally Graded Material to Decrease Maximum Temperature of a Coating-Substrate System. [PDF]

Materials (Basel), 2023
Yevtushenko A, Topczewska K, Zamojski P.
europepmc   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Non-linear buckling analysis of functionally graded shallow spherical shells

Vietnam Journal of Mechanics, 2009
In the present paper the non-linear buckling analysis of functionally graded spherical shells subjected to external pressure is investigated. The material properties are graded in the thickness direction according to the power-law distribution in terms ...
Dao Huy Bich
doaj   +1 more source

Synthesis and Characterization of a Titanium-Based Functionally Graded Material-Structured Biocomposite using Powder Metallurgy. [PDF]

ACS Omega, 2023
Ul Haq E, Ahmed F, U Rehman F, Channa IA, Makhdoom MA, Shahzad J, Shafiq T, Zain-Ul-Abdein M, Shar MA, Alhazaa A.   +9 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Evaluation of mechanical properties of Ni/BaTiO3 functionally graded material

Mechanics & Industry
A Ni-BaTiO3 functionally graded material (FGM) was elaborated from 5 separate layers, ranging from 0 to 100 wt.% Ni content, by Spark Plasma Sintering (SPS) method.
Saidani Baraa, Zghal Jihed, Bruant Isabelle, Bregiroux Damien, Petit Johann, Cedelle Julie, Chevallier Gaël   +6 more
doaj   +1 more source

In Vivo and In Vitro Analyses of Titanium-Hydroxyapatite Functionally Graded Material for Dental Implants. [PDF]

Biomed Res Int, 2021
Wang X, Wan C, Feng X, Zhao F, Wang H.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Inconel 625/AISI 413 Stainless Steel Functionally Graded Material Produced by Direct Laser Deposition. [PDF]

Materials (Basel), 2021
Ferreira AA, Emadinia O, Cruz JM, Reis AR, Vieira MF.   +4 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source