Results 61 to 70 of about 5,798,177 (248)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A quasi-3D theory for vibration and buckling of functionally graded sandwich beams [PDF]
, 2015 This paper presents a finite element model for free vibration and buckling analyses of functionally graded (FG) sandwich beams by using a quasi-3D theory in which both shear deformation and thickness stretching effects are included.
Thai, Huu-Tai +4 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Vibration and buckling analysis of functionally graded sandwich beams by a new higher-order shear deformation theory [PDF]
, 2015 This paper proposes a new higher-order shear deformation theory for buckling and free vibration analysis of isotropic and functionally graded (FG) sandwich beams.
Thai, Huu-Tai +3 more
core +1 more source
Results in Physics, 2020 An isogeometric numerical procedure based on non-uniform rational B-splines is applied to solve the free vibration of carbon nanotubes reinforced and functionally graded material sector cylindrical shells.
Yantao Zhang +4 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A finite element formulation for creep buckling analysis of Al–SiC functionally graded beams
Composites Part C: Open AccessA geometrically nonlinear finite element formulation is applied for the creep buckling analysis of Al–SiC functionally graded beam-type structures. The formulation is based on a co-rotational beam finite element, enabling the local evaluation of elastic ...
Raul Ivan Gašljević +2 more
doaj +1 more source