Results 51 to 60 of about 943,525 (345)

Size-dependent behaviour of functionally graded sandwich microbeams based on the modified couple stress theory [PDF]

open access: yes, 2015
Static bending, buckling and free vibration behaviours of size-dependent functionally graded (FG) sandwich microbeams are examined in this paper based on the modified couple stress theory and Timoshenko beam theory. To avoid the use of a shear correction
Thai, Huu-Tai   +3 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Bending and vibration of functionally graded material sandwich plates using an accurate theory

open access: yes, 2012
In this paper, the bending and the free flexural vibration behaviour of sandwich functionally graded material (FGM) plates are investigated using QUAD-8 shear flexible element developed based on higher order structural theory.
Ali   +21 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Vibration analysis of post-buckled fluid-conveying functionally graded pipe

open access: yesComposites Part C: Open Access, 2021
The vibration of post-buckled fluid-conveying pipe made of functionally graded material is analyzed. The pipe material properties are assumed to be graded in the thickness direction according to power-law distribution.
Abdellatif Selmi, Hedi Hassis
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

A micropolar model for elastic properties in functionally graded materials

open access: yesAdvances in Mechanical Engineering, 2018
By considering the description of phase volume fractions, a micromechanics model is presented for predicting the elastic mechanical properties of isotropic two-phase functionally graded materials. The particle size dependence of the overall elasticity of
Shengyao Fan, Zhanqi Cheng
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Torsion of Functionally Graded Material Structures: An Overview

open access: yesEngineering Transactions
Examining torsion in functionally graded materials (FGMs) is crucial because their properties vary spatially. FGMs with continuously graded architectures provide a robust basis for investigating mechanical behavior.
Mateusz Kumor, Artur Ganczarski
doaj   +1 more source

Structural Integrity of Functionally Graded Composite Structure using Mindlin-Type Finite Elements. [PDF]

open access: yes, 2008
In this paper, two new Mindlin-type plate bending elements have been derived for the modelling of functionally graded plate subjected to various loading conditions such as tensile loading, in-plane bending and out-of-plane bending.
El-Zafrany, A.   +2 more
core  

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