Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A refined higher-order shear deformation theory for bending, vibration and buckling analysis of functionally graded sandwich plates [PDF]
, 2015 A refined higher-order shear deformation theory for bending, vibration and buckling analysis of functionally graded sandwich plates is presented in this paper.
Thai, Huu-Tai, Vo, Thuc, Nguyen, Kien
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Structural Analysis of Functionally Graded Material Using Sigmioadal and Power Law
Diagnostyka, 2021 The stress-strain relations, displacement distribution, stress resultants and mid plane strain resultants of a functionally graded material plate are studied using Hamilton’s principle.
Nabel Kadum Abd-Ali, Ahmed Raee Madeh
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A size-dependent functionally graded sinusoidal plate model based on a modified couple stress theory [PDF]
, 2013 A size-dependent model for bending and free vibration of functionally graded plate is developed based on the modified couple stress theory and sinusoidal shear deformation theory.
Thai, Huu-Tai, Vo, Thuc
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A micropolar model for elastic properties in functionally graded materials
Advances in Mechanical Engineering, 2018 By considering the description of phase volume fractions, a micromechanics model is presented for predicting the elastic mechanical properties of isotropic two-phase functionally graded materials. The particle size dependence of the overall elasticity of
Shengyao Fan, Zhanqi Cheng
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Engineering Transactions, 2014 In this paper geometrically nonlinear analysis of functionally graded shells in 6-parameter shell theory is presented. It is assumed that the shell consists of two constituents: ceramic and metal.
Karol DASZKIEWICZ +2 more
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Refined shell elements for the analysis of functionally graded structures [PDF]
, 2011 The present paper considers the static analysis of plates and shells made of Functionally Graded Material (FGM), subjected to mechanical loads. Refined models based on the Carrera's Unified Formulation (CUF) are employed to account for grading material ...
DELLA CROCE L +19 more
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