Results 31 to 40 of about 20,756 (262)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On the Finite Element Implementation of Functionally Graded Materials [PDF]
Materials, 2019 We investigate the numerical implementation of functionally graded properties in the context of the finite element method. The macroscopic variation of elastic properties inherent to functionally graded materials (FGMs) is introduced at the element level by means of the two most commonly used schemes: (i) nodal based gradation, often via an auxiliary ...
openaire +4 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A micropolar model for elastic properties in functionally graded materials
Advances in Mechanical Engineering, 2018 By considering the description of phase volume fractions, a micromechanics model is presented for predicting the elastic mechanical properties of isotropic two-phase functionally graded materials. The particle size dependence of the overall elasticity of
Shengyao Fan, Zhanqi Cheng
doaj +1 more source
Vibration analysis of post-buckled fluid-conveying functionally graded pipe
Composites Part C: Open Access, 2021 The vibration of post-buckled fluid-conveying pipe made of functionally graded material is analyzed. The pipe material properties are assumed to be graded in the thickness direction according to power-law distribution.
Abdellatif Selmi, Hedi Hassis
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Torsion of Functionally Graded Material Structures: An Overview
Engineering TransactionsExamining torsion in functionally graded materials (FGMs) is crucial because their properties vary spatially. FGMs with continuously graded architectures provide a robust basis for investigating mechanical behavior.
Mateusz Kumor, Artur Ganczarski
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Energy capabilities of permeable thermoelectric coolers made of functionally graded materials
Технологія та конструювання в електронній апаратурі, 2004 A method is presented and results of computer design of permeable thermoelements made of functionally graded materials (FGM) for cooling a heat carrier blown through channels or pores in the branches are provided.
L. N. Vikhor, R. G. Cherkez
doaj