Results 91 to 100 of about 79,019 (297)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Vietnam Journal of Mechanics, 2016 In this paper, the free vibration of functionally sandwich grades plates with stiffeners is investigated by using the finite element method. The material properties are assumed to be graded in the thickness direction by a power-law distribution ...
Pham Tien Dat +2 more
doaj +1 more source
Static and Dynamic Thermomechanical Buckling Loads of Functionally Graded Plates. [PDF]
, 2013 In the paper the buckling phenomenon for static and dynamic loading (pulse of finite duration) of FGM plates subjected to simultaneous action of one directional compression and thermal field is presented.
Kowal-Michalska, Katarzyna +1 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Geometrically Nonlinear Vibrations of Functionally Graded Shallow Shells [PDF]
, 2016 An original method for investigation of geometrically nonlinear vibrations of functionally graded shallow shells and plates with complex planform is presented. Shells under consideration are made from a composite of ceramics and metal.
Bhaskar, A., Shmatko, T.
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Elastic-plastic analysis of functionally graded bars under torsional loading
, 2017 In this paper a new integral equation solution to the elastic-plastic problem of functionally graded bars under torsional loading is presented. The formulation is general in the sense that it can be applied to an arbitrary cross-section made of any type ...
Babouskos, Nick G., Tsiatas, George C.
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
VibrationThe viscoelastic behavior of functionally graded (FG) materials significantly affects their vibration performance, making it necessary to establish theoretical analysis methods.
Yuhua Cui +5 more
doaj +1 more source
Functionally Graded Porous Implants Obtained by Additive Manufacturing
Gazi Üniversitesi Fen Bilimleri Dergisi, 2019 Porous structures have an increasing use in the biomedical industry due to their advantage, such as supporting tissue regeneration for implants and prostheses used in the body, eliminating stress shielding and aseptic loosening problems.
Fahri MURAT +3 more
doaj +1 more source