Results 101 to 110 of about 79,751 (296)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Vietnam Journal of Mechanics, 2012 In this paper an approximate analytical solution to analyze the nonlinear buckling and postbuckling behavior of imperfect functionally graded panels with the Poisson's ratio also varying smoothly along the thickness is investigated.
Dao Van Dung, Le Kha Hoa
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Metal Based Functionally Graded Materials [PDF]
, 2010 The aim of this Ebook is to provide a comprehensive overview of the basic production techniques for manufacturing of metal-based graded materials. A concise description of experimental methods and short analysis of some specific structures obtained are presented.
openaire +2 more sources
Torsion of Functionally Graded Anisotropic Linearly Elastic Circular Cylinder
Engineering Transactions, 2018 The object of this paper is Saint-Venant torsion of functionally graded anisotropic linearly elastic circular cylinder. The class of anisotropy considered has at least one plane of elastic symmetry normal to the axis of the circular cylinder. The elastic
István ECSEDI, Attila BAKSA
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Self-vibration of thin plate band with non-linear functionally graded material
Archives of Mechanics, 2012 The subject of this paper is the analysis of free vibration of a thin plate band made of nonlinear functionally graded material. The considered material has periodic properties in one direction and slow but non-linear functionally graded properties in ...
A. Wirowski
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source