Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
FRACTURE ANALYSIS OF FUNCTIONALLY GRADED MATERIALS WITH COLLINEAR CRACKS
Jixie qiangdu, 2019 The fracture problem of the functionally graded material with collinear cracks under the condition of different elasticity moduli. The stress fields and displacement fields of cracks in the functionally graded strip can be obtained by means of the method
PAN HaiZhu +4 more
doaj
Natural Frequencies Optimization of Thin-Walled Circular Cylindrical Shells Using Axially Functionally Graded Materials. [PDF]
Materials (Basel), 2022 Alshabatat NT.
europepmc +1 more source
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
The Effect of Functionally Graded Materials on Temperature during Frictional Heating: Under Uniform Sliding. [PDF]
Materials (Basel), 2021 Yevtushenko A, Topczewska K, Zamojski P.
europepmc +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Crack Growth Simulation of Functionally Graded Materials Based on Improved Bond-Based Peridynamic Model. [PDF]
Materials (Basel), 2021 Min L, Liu Q, Liu L.
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Vibration Analysis of a Tetra-Layered FGM Cylindrical Shell Using Ring Support
MathematicsIn the present study, the vibration characteristics of a cylindrical shell (CS) made up of four layers are investigated. The ring is placed in the axial direction of a four-layered functionally graded material (FGM) cylindrical shell. The layers are made
Asra Ayub +3 more
doaj +1 more source
Three-Dimensional Free Vibration Analyses of Preloaded Cracked Plates of Functionally Graded Materials via the MLS-Ritz Method. [PDF]
Materials (Basel), 2021 Huang CS, Lee HT, Li PY, Chang MJ.
europepmc +1 more source