Results 91 to 100 of about 79,751 (296)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effective conductivity of composites of graded spherical particles

, 2005
We have employed the first-principles approach to compute the effective response of composites of graded spherical particles of arbitrary conductivity profiles. We solve the boundary-value problem for the polarizability of the graded particles and obtain
Arnold, Bollenbach, Chan, Dong, Dong, Fuhr, G.Q. Gu, Gu, Gu, Gu, Holt, Huang, Huang, Hughes, Ilschner, Jackson, K.W. Yu, Larson, Lin, Martin, Milton, Snyder, Wei, Yu, Yu   +24 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Application of functionally graded materials for severe plastic deformation and smart materials: experimental study and finite element analysis [PDF]

, 2012
Functionally graded materials (FGMs) refer to the composite materials where the compositions or the microstructures are locally varied so that a certain variation of the local material properties is achieved.
Jamian, Saifulnizan
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A Time-Domain Solution Method for the Vibration Performance of Viscoelastic Functionally Graded Porous Beams

Vibration
The viscoelastic behavior of functionally graded (FG) materials significantly affects their vibration performance, making it necessary to establish theoretical analysis methods.
Yuhua Cui, Tao Zeng, Yipeng Yang, Xiaohong Wang, Guodong Xu, Su Cheng   +5 more
doaj   +1 more source

Functionally Graded Porous Implants Obtained by Additive Manufacturing

Gazi Üniversitesi Fen Bilimleri Dergisi, 2019
Porous structures have an increasing use in the biomedical industry due to their advantage, such as supporting tissue regeneration for implants and prostheses used in the body, eliminating stress shielding and aseptic loosening problems.
Fahri MURAT, İsmail Hakkı KORKMAZ, Abdullah Tahir ŞENSOY, İrfan KAYMAZ   +3 more
doaj   +1 more source

Structural Integrity of Functionally Graded Composite Structure using Mindlin-Type Finite Elements. [PDF]

, 2008
In this paper, two new Mindlin-type plate bending elements have been derived for the modelling of functionally graded plate subjected to various loading conditions such as tensile loading, in-plane bending and out-of-plane bending.
El-Zafrany, A., Mba, David, Oyekoya, Oyedele O.   +2 more
core  

An asymptotically exact theory of functionally graded piezoelectric shells

, 2023
An asymptotically exact two-dimensional theory of functionally graded piezoelectric shells is derived by the variational-asymptotic method. The error estimation of the constructed theory is given in the energetic norm.
Le, Khanh Chau
core