Results 101 to 110 of about 80,406 (296)

Nonlinear analysis of buckling and postbuckling for axially compressed functionally graded cylindrical panels with the Poisson's ratio varying smoothly along the thickness

open access: yesVietnam Journal of Mechanics, 2012
In this paper an approximate analytical solution to analyze the nonlinear buckling and postbuckling behavior of imperfect functionally graded panels with the Poisson's ratio also varying smoothly along the thickness is investigated.
Dao Van Dung, Le Kha Hoa
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Metal Based Functionally Graded Materials [PDF]

open access: yes, 2010
The aim of this Ebook is to provide a comprehensive overview of the basic production techniques for manufacturing of metal-based graded materials. A concise description of experimental methods and short analysis of some specific structures obtained are presented.
openaire   +2 more sources

Torsion of Functionally Graded Anisotropic Linearly Elastic Circular Cylinder

open access: yesEngineering Transactions, 2018
The object of this paper is Saint-Venant torsion of functionally graded anisotropic linearly elastic circular cylinder. The class of anisotropy considered has at least one plane of elastic symmetry normal to the axis of the circular cylinder. The elastic
István ECSEDI, Attila BAKSA
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Self-vibration of thin plate band with non-linear functionally graded material

open access: yesArchives of Mechanics, 2012
The subject of this paper is the analysis of free vibration of a thin plate band made of nonlinear functionally graded material. The considered material has periodic properties in one direction and slow but non-linear functionally graded properties in ...
A. Wirowski
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Role of additive manufacturing in developing functionally graded materials for nuclear applications

open access: yesFrontiers in Nuclear Engineering
The global acceptance of additive manufacturing has evolved with time and has proven to provide promising solutions to varied critical requirements of the nuclear industry.
Amal Sasi, Madhulika Srivastava, K. Dash
doaj   +1 more source

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