Results 121 to 130 of about 79,019 (297)

Analytical Solution of Thermo-Mechanical Properties of Functionally Graded Materials by Asymptotic Homogenization Method. [PDF]

Materials (Basel), 2022
Chen D, Liu L, Chu L, Liu Q.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Vibration Analysis of a Tetra-Layered FGM Cylindrical Shell Using Ring Support

Mathematics
In the present study, the vibration characteristics of a cylindrical shell (CS) made up of four layers are investigated. The ring is placed in the axial direction of a four-layered functionally graded material (FGM) cylindrical shell. The layers are made
Asra Ayub, Naveed Hussain, Ahmad N. Al-Kenani, Madiha Ghamkhar   +3 more
doaj   +1 more source

Influence of Thermal Sensitivity of Functionally Graded Materials on Temperature during Braking. [PDF]

Materials (Basel), 2022
Yevtushenko A, Topczewska K, Zamojski P.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Spark Plasma Sintering of AlN/Al Functionally Graded Materials. [PDF]

Materials (Basel), 2021
Xiu Z, Ju B, Liu S, Song Y, Du J, Li Z, Zhou C, Yang W, Wu G.   +8 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Effect of Functionally Graded Materials on Temperature during Frictional Heating at Single Braking. [PDF]

Materials (Basel), 2021
Yevtushenko A, Topczewska K, Zamojski P.
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Natural Frequencies Optimization of Thin-Walled Circular Cylindrical Shells Using Axially Functionally Graded Materials. [PDF]

Materials (Basel), 2022
Alshabatat NT.
europepmc   +1 more source