Results 71 to 80 of about 80,406 (296)

A micropolar model for elastic properties in functionally graded materials

Advances in Mechanical Engineering, 2018
By considering the description of phase volume fractions, a micromechanics model is presented for predicting the elastic mechanical properties of isotropic two-phase functionally graded materials. The particle size dependence of the overall elasticity of
Shengyao Fan, Zhanqi Cheng
doaj   +1 more source

Stress concentration analysis in functionally graded plates with elliptic holes under biaxial

Ain Shams Engineering Journal, 2014
Stress concentration factors (SCFs) at the root of an elliptic hole in unidirectional functionally graded material (UDFGM) plates under uniaxial and biaxial loads are predicted. ANSYS Parametric Design Language (APDL) was used to build the finite element
Tawakol A. Enab
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Acoustic radiation characteristics of FG cylindrical shell based on Jacobi-Ritz modified boundary element method

Journal of Low Frequency Noise, Vibration and Active Control
In this paper, a semi-analytic method based on Jacobi-Ritz modified boundary element is proposed to solve the acoustic radiation response of functionally graded cylindrical shell.
Jiajun Zheng, Yuhang Tang, Haichao Li, Zhe Zhao, Fuzhen Pang, Cong Gao   +5 more
doaj   +1 more source

Digital fabrication of multi-material biomedical objects [PDF]

, 2009
This paper describes a multi-material virtual prototyping (MMVP) system for modelling and digital fabrication of discrete and functionally graded multi-material objects for biomedical applications.
Cheung, HH, Choi, SH
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Effects of thickness stretching in functionally graded plates and shells

, 2011
1The present work evaluates the effect of thickness stretching in plate/shell structures made by materials which are functionally graded (FGM) in the thickness directions.
Batra, Bayat, Birman, Brischetto, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Cauchy, Chi, Chi, Chiba, Estili, Ferreira, Haddadpour, Kashtalyan, Kashtalyan, Kirchhoff, Koizumi, Koizumi, Mindlin, Mori, Na, Pagano, Pagano, Pan, Poisson, Qian, Ramirez, Reissner, Vel, Vel, Zenkour   +37 more
core   +1 more source

Simulation and Validation of Three Dimension Functionally Graded Materials by Material Jetting [PDF]

, 2018
The goal of this work is to validate the material models for parts created with a Material Jetting 3-dimensional printer through the comparison of Finite Element Analysis (FEA) simulations and physical tests.
Baek, Dongcheon, Berndt, Aaron, Ryu, Jong Eun, Salcedo, Eduardo   +3 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source