Results 51 to 60 of about 12,472 (265)

Vibration and Static Analysis of Functionally Graded Porous Plates [PDF]

Journal of Applied and Computational Mechanics, 2017
This research deals with free vibration and static bending of a simply supported functionally graded (FG) plate with the porosity effect. Material properties of the plate which are related to its change are position-dependent.
Şeref Doğuşcan Akbaş
doaj   +1 more source

The Using of the Multilayer Plate Concept in the Calculus of Functionally Graded Plates

Applied Sciences, 2022
In the calculus of functionally graded plates, the concept of multilayer plate is often used. For the use of this concept in this calculus, the continuous variation of the respective properties is replaced with a step variation. The first problem that arises in front of the user is related to the number of layers, which must be a finite and reasonably ...
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Analysis of non symmetric FG sandwich plates under Thermo-mechanical loading using a novel shear deformation theory with stretching effect

MATEC Web of Conferences, 2018
The analysis of non-symmetric functionally graded sandwich plates under thermo-mechanical loading is developed using a novel hyperbolic shear deformation theory and considering thickness stretching effects.
Saidi H., Bouchafa A., Tounsi A., Adda.Bedia A. E.A.   +3 more
doaj   +1 more source

Computational modeling of sigmoid functionally graded material (SFGM) plate

Materials Research Express, 2023
The first-order shear deformation theory (FSDT) was used to explore the natural frequency response of functionally graded piezoelectric plates subjected to static electrical and mechanical strain in this present study.
Jai Kumar Sharma, Sateesh Kumar, Nishant Kumar, S M Mozammil Hasnain, Shatrudhan Pandey, Ahmed Farouk Deifalla, Adham E Ragab   +6 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Isogeometric Analysis for Active Control of Piezoelectric Functionally Graded Plates in Thermal Environment

Shock and Vibration, 2021
An isogeometric analysis (IGA) method is proposed for investigating the active shape and vibration control of functionally graded plates (FGPs) with surface-bonded piezoelectric materials in a thermal environment.
Tao Liu, Yafen Jiang, Shujun Li, Qingyun Liu, Chao Wang   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Nonlinear vibration of thick FGM plates on elastic foundation subjected to thermal and mechanical loads using the first-order shear deformation plate theory

Cogent Engineering, 2015
This paper presents an analytical approach to investigate the nonlinear dynamic response and vibration of thick functionally graded material (FGM) plates using both of the first-order shear deformation plate theory and stress function with full motion ...
Nguyen Dinh Duc, Pham Hong Cong
doaj   +1 more source