Results 71 to 80 of about 12,472 (265)

Vibration and Buckling Analysis of Functionally Graded Plates Using New Eight-Unknown Higher Order Shear Deformation Theory

Latin American Journal of Solids and Structures
In this paper a new eight-unknown higher order shear deformation theory is proposed to study the buckling and free vibration of functionally graded (FG) material plates.
Tran Ich Thinh, Tran Minh Tu, Tran Huu Quoc, Nguyen Van Long   +3 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Exact solution for bending analysis of functionally graded micro-plates based on strain gradient theory

Science and Engineering of Composite Materials, 2018
In the present article, static analysis of thin functionally graded micro-plates, based on Kirchhoff plate theory, is investigated. Utilizing the strain gradient theory and principle of minimum total potential energy, governing equations of rectangular ...
Mohammadi Meisam, Iranmanesh Afshin, Naseralavi Seyed Sadegh, Farahmand Hamed   +3 more
doaj   +1 more source

Buckling Behaviour of Functionally Graded Plates

Functionally graded materials (FGMs) have garnered significant attention in structural engineering due to their tailored material properties, offering enhanced mechanical performance compared to conventional homogeneous materials. This study investigates the buckling behaviour of functionally graded plates under various loading conditions and using ...
Akarsh M, Dr. Narayanan N I
openaire   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Analysis of Stability and Vibrations of Porous Power and Sigmoid Functionally Graded Sandwich Plates by the R-Functions Method

Journal of Mechanical Engineering, 2023
In this paper, the R-functions method is used for the first time to study the stability and vibrations of porous functionally graded (FG) sandwich plates with a complex geometric shape.
Lidiya V. Kurpa, Tetyana V. Shmatko, Anna B. Linnik   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

A New Hyperbolic Shear Deformation Theory for Bending Analysis of Functionally Graded Plates

Modelling and Simulation in Engineering, 2012
Theoretical formulation, Navier’s solutions of rectangular plates based on a new higher order shear deformation model are presented for the static response of functionally graded plates.
Tahar Hassaine Daouadji, Abdelaziz Hadj Henni, Abdelouahed Tounsi, Adda Bedia El Abbes   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source