Results 31 to 40 of about 43,304 (241)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Comparison moduli spaces of Riemann surfaces
, 2017 We define a kind of moduli space of nested surfaces and mappings, which we call a comparison moduli space. We review examples of such spaces in geometric function theory and modern Teichmueller theory, and illustrate how a wide range of phenomena in ...
Schippers, Eric, Staubach, Wolfgang
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Functions of Generalized Bounded Variation
, 2013 This thesis is devoted to the study of different generalizations of the classical conception of a function of bounded variation. First, we study the functions of bounded p-variation introduced by Wiener in 1924. We obtain estimates of the total p-variation (1<p<∞) and other related functionals for a periodic function f in Lp([0,1]) in terms of ...
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Regularizing effect of absorption terms in singular problems
, 2018 We prove existence of solutions to problems whose model is $$\begin{cases} \displaystyle -\Delta_p u + u^q = \frac{f}{u^\gamma} & \text{in}\ \Omega, \newline u\ge0 &\text{in}\ \Omega,\newline u=0 &\text{on}\ \partial\Omega, \end{cases ...
Oliva, Francescantonio
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Discretized Multinomial Distributions and Nash Equilibria in Anonymous Games
, 2008 We show that there is a polynomial-time approximation scheme for computing Nash equilibria in anonymous games with any fixed number of strategies (a very broad and important class of games), extending the two-strategy result of Daskalakis and ...
Daskalakis, Constantinos +1 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Cascade of minimizers for a nonlocal isoperimetric problem in thin domains
, 2014 For $\Omega_\e=(0,\e)\times (0,1)$ a thin rectangle, we consider minimization of the two-dimensional nonlocal isoperimetric problem given by \[ \inf_u E^{\gamma}_{\Omega_\e}(u)\] where \[ E^{\gamma}_{\Omega_\e}(u):= P_{\Omega_\e}(\{u(x)=1\})+\gamma\int_{\
Morini, Massimiliano, Sternberg, Peter
core +1 more source