Results 41 to 50 of about 895 (256)

Learning Recursive Functions from Approximations

open access: yes, 1997
This article investigates algorithmic learning, in the limit, of correct programs for recursive functionsffrom both input/output examples offand several interesting varieties ofapproximateadditional (algorithmic) information aboutf.
Case, John   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Generalizations Euler-Maclaurin-type inequalities for conformable fractional integrals [PDF]

open access: yes
In this study, we obtain a unique insight into differentiable convex functions by employing newly defined conformable fractional integrals. With this innovative approach, we unveil fresh Euler-Maclaurintype inequalities designed specifically for these ...
Budak, Huseyin   +4 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Functions of bounded variation, signed measures, and a general Koksma–Hlawka inequality [PDF]

open access: yesActa Arithmetica, 2015
In this paper we prove a correspondence principle between multivariate functions of bounded variation in the sense of Hardy and Krause and signed measures of finite total variation, which allows us to obtain a simple proof of a generalized Koksma--Hlawka inequality for non-uniform measures.
Aistleitner, Christoph, Dick, Josef
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

On the summability of double Walsh–fourier series of functions of bounded generalized variation [PDF]

open access: yesUkrainian Mathematical Journal, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Generalizations of Weighted Ostrowski Type Inequalities for Mappings of Bounded Variation and their Applications

open access: yes, 2006
In this paper, we establish some generalizations of weighted Ostrowski type Inequalities, and give several applications for r−moments, expectation of a continuous random variable and the Beta ...
Hwang, Shiow-Ru   +3 more
core  

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