Results 41 to 50 of about 43,304 (241)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Variational Methods and Planar Elliptic Growth [PDF]
, 2013 A nested family of growing or shrinking planar domains is called a Laplacian growth process if the normal velocity of each domain's boundary is proportional to the gradient of the domain's Green function with a fixed singularity on the interior.
Martin, Charles Z.
core
Limit law for some modified ergodic sums
, 2010 An example due to Erdos and Fortet shows that, for a lacunary sequence of integers (q_n) and a trigonometric polynomial f, the asymptotic distribution of normalized sums of f(q_k x) can be a mixture of gaussian laws.
Borgne, Stéphane Le, Conze, Jean-Pierre
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
, 2010 We consider extensions of Lemaitre-Tolman-Bondi (LTB) spacetimes to the dissipative case. For doing that we previously carry out a systematic study on LTB. This study is based on two different aspects of LTB.
A. Di Prisco +18 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
On generalizations of Fatou's theorem for the integrals with general kernels
, 2013 We define $\lambda(r)$-convergence, which is a generalization of nontangential convergence in the unit disc. We prove Fatou-type theorems on almost everywhere nontangential convergence of Poisson-Stiltjes integrals for general kernels $\{\varphi_r ...
Karagulyan, G. A., Safaryan, M. H.
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source