Results 41 to 50 of about 43,148 (240)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The fast escaping set for quasiregular mappings

open access: yes, 2013
The fast escaping set of a transcendental entire function is the set of all points which tend to infinity under iteration as fast as compatible with the growth of the function. We study the analogous set for quasiregular mappings in higher dimensions and
Bergweiler, Walter   +2 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Variational Methods and Planar Elliptic Growth [PDF]

open access: yes, 2013
A nested family of growing or shrinking planar domains is called a Laplacian growth process if the normal velocity of each domain's boundary is proportional to the gradient of the domain's Green function with a fixed singularity on the interior.
Martin, Charles Z.
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

On generalizations of Fatou's theorem for the integrals with general kernels

open access: yes, 2013
We define $\lambda(r)$-convergence, which is a generalization of nontangential convergence in the unit disc. We prove Fatou-type theorems on almost everywhere nontangential convergence of Poisson-Stiltjes integrals for general kernels $\{\varphi_r ...
Karagulyan, G. A., Safaryan, M. H.
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

On embeddings between spaces of functions of generalized bounded variation

open access: yes, 2018
In this note, we aim to establish a number of embeddings between various function spaces that are frequently considered in the theory of Fourier series. More specifically, we give sufficient conditions for the embeddings $ V[h]\subseteq \text{BV}^{(p_n\uparrow p)}$, $ V[h_1]^{(p)}\subseteq V[h_2]^{(q)}$ and $ \text{BV}^{(p_n\uparrow p)}\subseteq
Esslamzadeh, G. H., Goodarzi, M. Moazami
openaire   +2 more sources

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