Results 41 to 50 of about 399,252 (315)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Two remarks on properties of functions of bounded variation

Вестник Самарского университета: Естественнонаучная серия
In terms of variations, a sufficient condition for the uniform convergence of sequences of continuous functions is proved. Using this result, we obtain an addition to the classical Helly theorem on the selection of convergent sequences of functions with ...
Sergey V. Astashkin, Vladislav M. Ershov
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Functions of bounded (2,k)-variation in 2-normed spaces

AIMS Mathematics
In this work, the notion of function of bounded variation in 2-normed spaces was established (Definition 4.2), the set of functions of bounded $ (2, k) $-variation was endowed with a norm (Theorem 4.5), and it was proved that such a set is a Banach space
Cure Arenas Jaffeth , Ferrer Sotelo Kandy , Ferrer Villar Osmin   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Perturbed Companions of Ostrowski’s Inequality for Absolutely Continuous Functions (I)

Annals of the West University of Timisoara: Mathematics and Computer Science, 2016
Perturbed companions of Ostrowski’s inequality for absolutely continuous functions whose derivatives are either bounded or of bounded variation and applications are given.
Dragomir Silvestru Sever
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Impulsive Control Systems with Trajectories of Bounded p-Variation

Известия Иркутского государственного университета: Серия "Математика", 2017
The paper deals with impulse-trajectory relaxations of control-affine systems under the assumption that $L_1$-norms of the control functions are not uniformly bounded. Generalized solutions of such control systems may be of infinite total variation. Most
O.N. Samsonyuk, M. V. Staritsyn
doaj   +1 more source

On the Analytic Structure of Second-Order Non-Commutative Probability Spaces and Functions of Bounded Fréchet Variation [PDF]

, 2022
Mario Dı́az, James A. Mingo
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source