Results 81 to 90 of about 399,252 (315)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Locally Lipschitz Composition Operators in Space of the Functions of Bounded
, 2014 Odalis Mejía +2 more
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Minimizing Functions with Bounded Variation of Subgradients [PDF]
SSRN Electronic Journal, 2005 In many applications it is possible to justify a reasonable bound for possible variation of subgradients of objective function rather than for their uniform magnitude. In this paper we develop a new class of efficient primal-dual subgradient schemes for such problem classes.
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On functions of bounded ω-variation, II [PDF]
Journal of the Australian Mathematical Society, 1965 Let ω(x) be a non-decreasing function defined in the interval [a, b]. We extend the definition to all x by taking ω(x) = ω(a) for x < a and ω(x) = ω(b) for x > b. R. L. Jeffery [2] has denoted by the class of functions F(x) defined as follows:
openaire +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
On convergence of Chlodovsky type Durrmeyer polynomials in variation seminorm
Journal of Numerical Analysis and Approximation Theory, 2018 This paper deals with the variation detracting property and rate of approximation of the Chlodovsky type Durrmeyer polynomials in the space of functions of bounded variation with respect to the variation seminorm.
Özlem Öksüzer Yilik +2 more
doaj +2 more sources
About the general chain rule for functions of bounded variation [PDF]
, 2023 Camillo Brena, Nicola Gigli
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