Results 31 to 40 of about 17,091 (293)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

The Forgotten Fundamental Freedoms of the Charter

open access: yes, 2020
This collection of 13 papers examines many of the freedoms listed in section 2 of the Charter that have been “forgotten” in the sense that they have not received (much) interpretation in jurisprudence or discussion in legal scholarship.
Bird, Brian   +3 more
core   +1 more source

A Comparative Study of the Theoretical Foundations of Liberal States and the Views of John Rawls [PDF]

open access: yesحقوق عمومی تطبیقی
The discourse and theories of governance are among the important subjects in the field of public law. Liberal and constitutional states, despite their theoretical and sometimes functional differences, share certain common elements as theories of ...
Abdolsaeid Shojai, ehsan movahedi pour
doaj   +1 more source

Les solidarités territoriales à l’aune de l’intelligence artificielle : quelle fonction pour le droit ?

open access: yesCommunication, Technologies et Développement, 2022
The solidarist conception of administrative action that has developed within local authorities can, in certain respects, be upset by the arrival of artificial intelligence.
Julien VIEIRA
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Restrângerea exercițiului drepturilor și libertăților fundamentale prin decretele instituind sau prelungind starea de urgență sau de asediu și prin ordonanțele militare [PDF]

open access: yesForum Juridic, 2020
The Romanian Constitution authorizes the restriction of the exercise of fundamental rights and freedoms only by law. The decrees of the President of Romania establishing or prolonging the state of emergency or the state of siege and the military ...
Corneliu-Liviu Popescu
doaj  

LEGAL GROUNDS FOR RESTRICTIONS OF HUMAN RIGHTS IN THE EUROPEAN COURT OF HUMAN RIGHTS CASE-LAW

open access: yesAccess to Justice in Eastern Europe, 2021
This article is devoted to the study of the legal grounds for restrictions of human rights in the ECtHR’s case-law. The study stipulates that the concept of generations of human rights, based on the historical progress of ensuring human rights and ...
Koruts Uliana
doaj   +1 more source

Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini   +28 more
wiley   +1 more source

Human Rights and Fundamental Freedoms in Athenian Oratory [PDF]

open access: yes, 2021
Human rights and fundamental freedoms are entitlements thought to be inherent to humans, shared equally by all and thought to exist beyond the authority of any human institution or structure.
Tan, Lucian
core  

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