Results 91 to 100 of about 8,493,253 (253)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mısır’ın Tavuk Fabrikaları [PDF]
, 2015 Mısır’da, 13. asırdan beri enteresan bir gelenek devam etmekte. On binlerce yumurta, gübre fırınlarında kuluçkaya yatırılmakta… Seyahatnamelerle dünyaya yayılan bu hadise Avrupa’da onlarca makaleye konu olmuş.
Sen, H. +2 more
core
On the number of certain del Pezzo surfaces of degree four violating the Hasse principle [PDF]
, 2016 We give an asymptotic expansion for the density of del Pezzo surfaces of degree four in a certain Birch Swinnerton-Dyer family violating the Hasse principle due to a Brauer-Manin obstruction.
Fundamental mathematics +3 more
core +1 more source
Green’s Function for Non-Homogeneous Magneto-Electro-Elastic Half-Plane
Engineering ProceedingsAn exponentially graded magneto-electro-elastic (MEE) half-plane subjected to anti-plane mechanical and in-plane electric and magnetic time-harmonic external load is considered.
Yonko Stoynov
doaj +1 more source
Computer Assisted Methods in Engineering and Science, 2017 We conducted thermal conductivity investigations by homogenization. This method can effectively model structural features such as pores within dispersed particle architectures via a finite element mesh.
Yusuke Asakuma, Tsuyoshi Yamamoto
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source