Results 101 to 110 of about 4,693,472 (296)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
On finding the fundamental matrix of finite state homogeneous Markov chains in special case
, 2010 For a Їnite state homogeneous Markov chain with circulant transition matrix that describes shift register that clocks 1,2 times with probabilities p; q we have found fundamental matrix.
Gaiduk, A. N.
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Robust Fundamental Matrix Determination without Correspondences [PDF]
, 2005 Estimation of the fundamental matrix is key to many problems in computer vision as it allows recovery of the epipolar geometry between camera images of the same scene.
Bradley, Andrew P. +4 more
core +1 more source
Nano-Micro LettersHighlights A novel anisotropic sensor with oriented piezoelectric filaments was prepared, capable of detecting both the magnitude and direction of micro-deformations.
Hao Yin +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Positivity of Fundamental Matrix and Exponential Stability of Delay Differential System
Abstract and Applied Analysis, 2014 The classical Wazewski theorem established that nonpositivity of all nondiagonal elements pij (i≠j, i,j=1,…,n) is necessary and sufficient for nonnegativity of the fundamental (Cauchy) matrix and consequently for applicability of the Chaplygin approach
Alexander Domoshnitsky +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
On the Direct Estimation of the Fundamental Matrix
, 2008 The fundamental matrix is a central construct in the analysis of images captured from a pair of cameras and many feature-based methods have been proposed for its computation. In this paper, we propose a direct method for estimating the fundamental matrix
Yaser Sheikh
core