Results 51 to 60 of about 1,795,694 (242)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

On the periodic solutions of linear homogenous systems of differential equations

International Journal of Mathematics and Mathematical Sciences, 1982
Given a fundamental matrix ϕ(x) of an n-th order system of linear homogeneous differential equations Y′=A(x)Y, a necessary and sufficient condition for the existence of a k-dimensional (k≤n) periodic sub-space (of period T) of the solution space of the ...
A. K. Bose
doaj   +1 more source

On Fundamental Solution for Autonomous Linear Retarded Functional Differential Equations

Mathematics, 2020
This document focuses attention on the fundamental solution of an autonomous linear retarded functional differential equation (RFDE) along with its supporting cast of actors: kernel matrix, characteristic matrix, resolvent matrix; and the Laplace ...
Clement McCalla
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Vortex counting from field theory

, 2012
The vortex partition function in 2d N = (2,2) U(N) gauge theory is derived from the field theoretical point of view by using the moduli matrix approach.
A Achucarro, A Achucarro, A Adams, A Belavin, A Hanany, A Hanany, A Miyake, A Penin, AD Popov, C-S Lin, CA Keller, D Tong, E Witten, F Fucito, G Bonelli, G Bonelli, G Lozano, GW Moore, H-Y Chen, J Baptista, J Baptista, Keisuke Ohashi, LF Alday, M Edalati, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Eto, M Shifman, M Shifman, M Shifman, M Shifman, Muneto Nitta, N Dorey, N Dorey, N Dorey, N Nekrasov, N Seiberg, N Seiberg, NA Nekrasov, NS Manton, NS Manton, S Shadchin, SC Davis, T Dimofte, T Fujimori, T Fujimori, T Kimura, T Kimura, T Kimura, T Nishioka, T Vachaspati, Taro Kimura, Toshiaki Fujimori, U Bruzzo, V Belavin, Y Isozumi   +67 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Boundary value problem for system of finite-difference with averaging equations

Журнал Белорусского государственного университета: Математика, информатика, 2018
The boundary value problem for the system of linear nonhomogeneous differential equations with generalized coefficients is considered X(t) = L(t)X(t) + F(t), M1X(0) + M2X(b) = Q, where t ∈ T = [0, b], L : T → Rpxp and F : T → Rp are right-continuous ...
Sergey A. Spaskov, Anton K. Khmyzov
doaj  

Dynamical and Quenched Random Matrices and Homolumo Gap

, 2017
We consider a rather general type of matrix model, where the matrix M represents a Hamiltonian of the interaction of a bosonic system with a single fermion.
Andric, Ivan, Jonke, Larisa, Jurman, Danijel, Nielsen, Holger Bech   +3 more
core   +1 more source