Results 71 to 80 of about 1,795,694 (242)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Holographic Geometry and Noise in Matrix Theory

, 2009
Using Matrix Theory as a concrete example of a fundamental holographic theory, we show that the emergent macroscopic spacetime displays a new macroscopic quantum structure, holographic geometry, and a new observable phenomenon, holographic noise, with ...
Craig J. Hogan, G. ’t Hooft, J. M. Maldacena, Mark G. Jackson   +3 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Analysis of planar‐motion segmentation using affine fundamental matrix

IET Computer Vision, 2014
Various computer‐vision applications involve estimation of multiple motions from images of dynamic scenes. The exact nature of 3D‐object motions and the camera parameters are often not known a priori and therefore, the most general motion model ...
Shafriza Nisha Basah, Alireza Bab‐Hadiashar, Reza Hoseinnezhad   +2 more
doaj   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Ultra-High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

Nano-Micro Letters
Highlights A novel anisotropic sensor with oriented piezoelectric filaments was prepared, capable of detecting both the magnitude and direction of micro-deformations.
Hao Yin, Yanting Li, Zhiying Tian, Qichao Li, Chenhui Jiang, Enfu Liang, Yiping Guo   +6 more
doaj   +1 more source

Poles in the $S$-Matrix of Relativistic Chern-Simons Matter theories from Quantum Mechanics

, 2015
An all orders formula for the $S$-matrix for 2 $\rightarrow$ 2 scattering in large N Chern-Simons theory coupled to a fundamental scalar has recently been conjectured.
Dandekar, Yogesh, Mandlik, Mangesh, Minwalla, Shiraz   +2 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fundamental Solution of Elliptic Equation with Positive Definite Matrix Coefficient

Cauchy: Jurnal Matematika Murni dan Aplikasi, 2018
In this paper, we study the fundamental solution of elliptic equations with real constant coefficients   where is a positive definite matrix. We obtained by searching the radial solution so that we solved the equation into ordinary differential equations.
Khoirunisa Khoirunisa, Corina Karim
doaj   +1 more source