Results 141 to 150 of about 31,277 (241)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Fundamental Motor Skills Assessments Predicting Academic Performance: A Systematic Review. [PDF]

Med J Islam Repub Iran
Berahimi E, Fatorehchy S, Nobahar Ahari M, Askary Kachoosangy R.   +3 more
europepmc   +1 more source

Effects of Combined Movement and Storytelling Intervention on Fundamental Motor Skills, Language Development and Physical Activity Level in Children Aged 3 to 6 Years: Study Protocol for a Randomized Controlled Trial. [PDF]

Children (Basel), 2023
Vargas-Vitoria R, Faúndez-Casanova C, Cruz-Flores A, Hernandez-Martinez J, Jarpa-Preisler S, Villar-Cavieres N, González-Muzzio MT, Garrido-González L, Flández-Valderrama J, Valdés-Badilla P.   +9 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of physical activity on fundamental motor skills and body composition in children and adolescents with intellectual and developmental disabilities: a systematic review and meta-analysis. [PDF]

PeerJ
Tan X, Zhang L, Wang D, Wu X.
europepmc   +1 more source

Caffeine Produces Neutral Effects on Extraverts' and Introverts' Performance of Fundamental Motor Skills. [PDF]

J Hum Kinet, 2021
Carolina Gomes A, Tosini L, Oliveira D, Lage G, Franchini E, Meira C.   +5 more
europepmc   +1 more source

Factors Related to the Fundamental Motor Skills in Preschool Children

, 2017
Fundamental motor skills affect children’s physical, social, and cognitive development. The aim of this research was to determine the influence of body mass index, motor abilities, physical activity and sedentary behavior of parents on fundamental motor skills of preschool children. Participants were 103 parent-child dyads from one child care center in
Nikolić, Ivana, Mraković, Snježana, Hraski, Marijana   +2 more
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A school-family blended multi-component physical activity program for Fundamental Motor Skills Promotion Program for Obese Children (FMSPPOC): protocol for a cluster randomized controlled trial. [PDF]

BMC Public Health, 2023
Zhou L, Liang W, He Y, Duan Y, Rhodes RE, Lippke S, Baker JS, Liang Y, Han L, Liu WX, Liu Q.   +10 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source