Results 181 to 190 of about 206,533 (326)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

On the Maximum Mass and Oblateness of Rotating Neutron Stars with Generic Equations of State

The Astrophysical Journal
A considerable effort has been dedicated recently to the construction of generic equations of state (EOSs) for matter in neutron stars. The advantage of these approaches is that they can provide model-independent information on the interior structure and
Carlo Musolino, Christian Ecker, Luciano Rezzolla   +2 more
doaj   +1 more source

The magnetic fields of intermediate-mass T Tauri stars : I. Magnetic detections and fundamental stellar parameters [PDF]

, 2018
F. Villebrun, E. Alécian, G. A. J. Hussain, J. Bouvier, C. P. Folsom, Y. Lebreton, Louis Amard, C. Charbonnel, F. Gallet, L. Haemmerlé, T. Böhm, Christopher M. Johns‐Krull, O. Kochukhov, S. C. Marsden, J. Morin, P. Petit   +15 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

High-resolution Spectroscopic Analysis of Four Unevolved Barium Stars

The Astronomical Journal
A classical local thermodynamic equilibrium analysis, based on high-resolution spectroscopic data, is performed for a sample of three potential barium dwarf candidates and one star already recognized as such.
M. P. Roriz, N. Holanda, L. V. da Conceição, S. Junqueira, N. A. Drake, A. Sonally, C. B. Pereira   +6 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Photometric Analysis of 30 Contact Binaries in M31

The Astrophysical Journal
M31, as the largest galaxy in the Local Group, is of significant importance for the study of stellar formation and evolution. Based on the data of 5859 targets observed in M31 by Gu et al., we selected 30 contact binaries by visual inspection for further
Xiang Gao, Kai Li, Li-Heng Wang, Hai-bo Yuan, Hong-rui Gu, Ya-Ni Guo   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Fast Rotation vs. Metallicity

, 2005
Fast rotation seems to be the major factor to trigger the Be phenomenon. Surface fast rotation can be favored by initial formation conditions such as metal abundance.
Fremat, Yves, Leister, Nelson Vani, Levenhagen, Ronaldo, Zorec, Juan   +3 more
core   +1 more source

FUNDAMENTAL PARAMETERS OF SUPERGİANT STAR HD40589(A0Iab)

Odesa Astronomical Publications
У цій роботі були визначені фундаментальні параметри зорі-надгігінта HD 40589 (A0Iab), а саме ефективна температура (T eff ), прискорення сили тяжіння (log g), мікротурбулентна швидкість (ξt) і металічність [Fe/H]. Відстань до зорі 1734 пк. Висота над площиною Галактики становить 67,5 пк.
openaire   +1 more source