Results 141 to 150 of about 2,640,436 (349)

Solving the Amyloid Paradox: Unveiling the Complex Pathogenicity of Amyloid Fibrils

open access: yesAggregate, EarlyView.
This review addresses the gap between strong evidence for the involvement of amyloid fibrils in neurodegeneration and the failure of anti‐amyloid therapies, a phenomenon herein termed the “amyloid paradox.” To address this paradox, we provide a comprehensive summary of the current understanding of fibrils' pathogenic properties and mechanisms ...
Maksim I. Sulatsky   +3 more
wiley   +1 more source

DNA damage induced by hydroquinone can be prevented by fungal detoxification

open access: yesToxicology Reports, 2014
Hydroquinone is a benzene metabolite with a wide range of industrial applications, which has potential for widespread human exposure; however, the toxicity of hydroquinone on human cells remains unclear. The aims of this study are to investigate the cytotoxicity and genotoxicity of hydroquinone in human primary fibroblasts and human colon cancer cells (
Pereira, Pedro   +3 more
openaire   +5 more sources

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

open access: yesAggregate, EarlyView.
Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong   +3 more
wiley   +1 more source

SWI/SNF complex-mediated chromatin remodeling in Candida glabrata promotes immune evasion

open access: yesiScience
Summary: Immune evasion is critical for fungal virulence. However, how the human opportunistic pathogen Candida glabrata (Cg) accomplishes this is unknown. Here, we present the first genome-wide nucleosome map of the macrophage-internalized Cg consisting
Kundan Kumar   +2 more
doaj  

Mycosis Fungoides, Sézary Syndrome, and Cutaneous B‐Cell Lymphomas: 2025 Update on Diagnosis, Risk‐Stratification, and Management

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT Disease Overview Primary cutaneous lymphomas are a rare and heterogeneous group of extranodal lymphomas that require the integration of clinical and histopathologic data for classification and treatment. Diagnosis Diagnosis and disease classification is based on histopathologic review and immunohistochemical staining of an appropriate skin ...
Alexandra C. Hristov   +2 more
wiley   +1 more source

Protocol for determination of phosphatidylinositol 3-phosphate levels and localization in Candida glabrata by confocal microscopy

open access: yesSTAR Protocols
Summary: Phosphatidylinositol 3-phosphate (PI3P) levels govern membrane trafficking in Candida glabrata. Here, we present a confocal imaging-based protocol for PI3P localization analysis using the GFP-FYVE (found in Fab1, YOTB, Vac1, and EEA1) fusion ...
Fizza Askari, Rupinder Kaur
doaj  

Dual DNA Barcoding for the Molecular Identification of the Agents of Invasive Fungal Infections

open access: yesFrontiers in Microbiology, 2019
Invasive fungal infections, such as aspergillosis, candidiasis, and cryptococcosis, have significantly increased among immunocompromised people. To tackle these infections the first and most decisive step is the accurate identification of the causal ...
Minh Thuy Vi Hoang   +58 more
doaj   +1 more source

Development of a Highly Sensitive FcMito qPCR Assay for the Quantification of the Toxigenic Fungal Plant Pathogen Fusarium culmorum

open access: yesToxins, 2018
Fusarium culmorum is a ubiquitous, soil-borne fungus (ascomycete) causing foot and root rot and Fusarium head blight on cereals. It is responsible for yield and quality losses as well as grain contamination with mycotoxins, which are a potential health ...
Katarzyna Bilska   +11 more
doaj   +1 more source

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