Results 31 to 40 of about 788,292 (257)

A Fun-Guide to Innate Immune Responses to Fungal Infections

Journal of Fungi, 2022
Immunocompromised individuals are at high risk of developing severe fungal infections with high mortality rates, while fungal pathogens pose little risk to most healthy people.
Thomas B. Burgess, Alison M. Condliffe, Philip M. Elks   +2 more
doaj   +1 more source

Significant differences in intestinal fungal community of hooded cranes along the wintering periods

Frontiers in Microbiology, 2022
The intestinal microbiota play vital roles for health of wild birds in many ways. Migratory birds with unique life history might increase the risk of pathogenic transmission across the regions.
Yuannuo Wu, Yuannuo Wu, Zihan Li, Jingru Zhao, Jingru Zhao, Zhong Chen, Zhong Chen, Xingjia Xiang, Xingjia Xiang, Xingjia Xiang   +9 more
doaj   +1 more source

Climate-Fungal Pathogen Modeling Predicts Loss of Up to One-Third of Tea Growing Areas

Frontiers in Cellular and Infection Microbiology, 2021
Climate change will affect numerous crops in the future; however, perennial crops, such as tea, are particularly vulnerable. Climate change will also strongly influence fungal pathogens. Here, we predict how future climatic conditions will impact tea and
Saowaluck Tibpromma, Saowaluck Tibpromma, Saowaluck Tibpromma, Yang Dong, Yang Dong, Sailesh Ranjitkar, Sailesh Ranjitkar, Douglas A. Schaefer, Samantha C. Karunarathna, Samantha C. Karunarathna, Samantha C. Karunarathna, Kevin D. Hyde, Kevin D. Hyde, Ruvishika S. Jayawardena, Ishara S. Manawasinghe, Daniel P. Bebber, Itthayakorn Promputtha, Itthayakorn Promputtha, Jianchu Xu, Jianchu Xu, Jianchu Xu, Peter E. Mortimer, Jun Sheng   +22 more
doaj   +1 more source

Biphasic Regulation of Epithelial Antimicrobial Peptides During Candida albicans Vaginal Infection: Distinct Contributions of NLRP3/IL-1β and IL-17RA Pathways to β-Defensin-1 and -3 Expression

Journal of Fungi
Candida albicans is the primary agent of acute vulvovaginal candidiasis (VVC) and its recurrent form (RVVC). Local innate immunity contributes to both defense and pathogenesis during vaginal Candida infection, where epithelial β-defensins (BD) constitute
Sofía Carla Angiolini, Emilse Rodriguez, Clarisa Manzone-Rodriguez, Paula Alejandra Icely, María Soledad Miró, Fernando Oscar Riera, Pablo Iribarren, Juan Pablo Caeiro, Claudia Elena Sotomayor   +8 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections

, 2023
Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such infections have been frequently reported worldwide and are currently gaining clinical research relevance ...
Caroline Patini Rezende, Leonardo Martins-Santana, Antonio Rossi, Fausto Almeida, Nilce Maria Martinez-Rossi   +4 more
core   +1 more source

Transcontinental Dispersal of Nonendemic Fungal Pathogens through Wooden Handicraft Imports

mBio, 2022
This study examined the viability and diversity of fungi harbored in imported wooden handicraft products sold in six retail stores in Florida, United States.
Jason A. Smith, Tania Quesada, Gideon Alake, Nicolas Anger   +3 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source