Results 71 to 80 of about 25,541 (294)

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

Fungicidal activity of some o-nitrophenyl-hydrazones.

Farmaco (Societa chimica italiana : 1989), 1996
The antimycotic activity of 16 o-nitrophenylhydrazones against strains of Hansenula anomala, Saccharomyces cerevisiae, Candida parapsylosis, and Cryptococcus albidus was tested. All 16 compounds inhibited growth of the yeast strains. The inhibitory activity of the 4 methyl-derivatives substituted on the aromatic nucleus was particularly significant.
Boatto, Gianpiero, Asproni, Battistina, Cerri, Riccardo, Palomba, Michele Francesco Luigi, Pau, Amedeo, Pintore, Giorgio Antonio Mario, Farris, Giovanni Antonio   +6 more
openaire   +5 more sources

The Inter-generic Fungicidal Activity of Xanthophyllomyces dendrorhous [PDF]

, 2010
Artículo de publicación ISIIn this study, the existence of intra-specific and inter-generic fungicidal activity in Xanthophyllomyces dendrorhous and Phaffia rhodozyma strains isolated from different regions of the earth was examined.
Cifuentes Guzmán, Víctor, Marcelo Baeza, Baeza Cancino, Marcelo, Mario Carrasco, Oviedo, Vicente, Oriana Flores, Rozas, Juan Manuel, Barahona‑Crisóstomo, Salvador, Juan Manuel Rozas, Víctor Cifuentes, Carrasco, Mario, Salvador Barahona, Flores, Oriana, Vicente Oviedo   +13 more
core   +1 more source

A Strong Lewis Acidic Diethylsilylium Catalyst for Direct Sulfonamidation of Challenging Ketones

Advanced Science, EarlyView.
Low‐substitution‐order silylium ions (R2HSi+) exhibit exceptional Lewis acidic activity. We report diethylsilylium‐catalyzed reductive sulfonamidation of functionalized ketones to access β‐amino esters. The in situ generated ion pair shows enhanced reactivity, with diethylsilane serving as both reductant and precatalyst. The developed protocol proceeds
Woo Hee Kim, Muhammad Israr, You Kyoung Chung, Shinwon Ham, Joonsuk Huh, Han Yong Bae   +5 more
wiley   +1 more source

Investigating the combined effects of binary mixtures comprising essential oils and Azole fungicides on some plant pathogenic fungi [PDF]

Journal of Crop Protection
Combinations of traditional fungicides and natural compounds have the potential to produce more effective antifungal activity at sufficiently low concentrations.
Mohsen Abbod, Ezzat Khallouf
doaj   +1 more source

Peptides of the Constant Region of Antibodies Display Fungicidal Activity

, 2012
Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata,
Pinto MR, Arruda, Denise C. [UNIFESP], Polonelli Luciano, De Bernardis Flavia, Silvia Arancia, Pertinhez, Thelma A., Luciano Polonelli, Arancia S, Polonelli, Luciano, Gabrielli E, Travassos Luiz R., Anna Vecchiarelli, Magliani Walter, Spisni, Alberto, Stefania Conti, Pinto Marcia R., S. Arancia, Pier Paolo Zanello, Denise C Arruda, D. C. Arruda, De Bernardis F, Elena Gabrielli, Zanello, Pier Paolo, Galati Serena, Ciociola T, Eva Pericolini, Arruda, Denise C., Zanello Pier Paolo, MAGLIANI, Valter, Conti, Stefania, D'Adda Tiziana, D'Adda T, De Bernardis, Flavia, Pericolini, Eva, Conti S., Tiziana D'Adda, Pinto, Marcia R., Arruda DC, Pertinhez TA, Arancia Silvia, Alberto Spisni, Vecchiarelli A, D'Adda, Tiziana, Serena Galati, Vecchiarelli, Anna, Gabrielli Elena, Thelma A Pertinhez, Arancia, Silvia, L. R. Travassos, Zanello PP, Gabrielli, Elena, Galati, Serena, Ciociola Tecla, Spisni Alberto, Travassos, Luiz R., Magliani W, M. R. Pinto, Magliani, Walter, Galati S, Luiz R Travassos, E. Pericolini, Polonelli L, F. De Bernardis, A. Vecchiarelli, Vecchiarelli Anna, Ciociola, Tecla, Conti Stefania, Arruda Denise C., Marcia R Pinto, Pertinhez Thelma A., Spisni A, Flavia De Bernardis, Pericolini Eva, Walter Magliani, Travassos LR, E. Gabrielli, Tecla Ciociola, PERTINHEZ, Thelma, Travassos, Luiz Rodolpho [UNIFESP]   +78 more
core   +1 more source

Multi‐Stimuli‐Responsive Hydrogen‐Bonded Organic Frameworks Nanocarriers Enable Targeted Fungicide Release and Plant Immune Regulation

Advanced Science, EarlyView.
A fluorinated hydrogen‐bonded organic framework nanocarrier (PFC‐1‐F) loaded with PYR and coated with HACC enables multi‐stimuli‐responsive (enzyme/ROS/pH) release at infection sites. Exhibiting targeted antifungal activity against Sclerotium rolfsii, modulating plant antioxidant defense, and demonstrating favorable biosafety across plant, soil, and ...
Guangming Ma, Ying Zou, Yao Wang, Huiyan Li, Jinlin Li, Tianfu Liu, Xiaohong Pan   +6 more
wiley   +1 more source

Kinetics and requirements for activation of macrophages for fungicidal activity: Effect of protein synthesis inhibitors and immunosuppressants on activation and fungicidal mechanism

Cellular Immunology, 1991
Peritoneal-and pulmonary macrophages can be activated in vitro with lymphokines (LK) or IFN-gamma, without exogenous lipopolysaccharide, for fungicidal activity against several pathogenic fungi. However, neither the biochemical nor metabolic events of the activation process or of the effector phase have been defined.
E, Brummer, L H, Hanson, D A, Stevens
openaire   +2 more sources

Synthesis and fungicidal activity of aryl(arylamino)methylphosphonic acids

, 2016
A series of aryl(arylamino)methylphosphonic acids were synthesized based on the previous work for the modification of alkylphosphonates. As key intermediates, α-aminophosphonates were synthesized with high yield by a three-component Kabachnik–Fields ...
Hongwu He (509463), Haiqin Wang (1402000), Hao Peng (231482)   +2 more
core   +1 more source