Results 81 to 90 of about 25,541 (294)

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Identification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening

mBio, 2016
Cryptococcus neoformans is a pathogenic fungus that is responsible for up to half a million cases of meningitis globally, especially in immunocompromised individuals. Common fungistatic drugs, such as fluconazole, are less toxic for patients but have low
Yoon-Dong Park, Wei Sun, Antonio Salas, Avan Antia, Cindy Carvajal, Amy Wang, Xin Xu, Zhaojin Meng, Ming Zhou, Gregory J. Tawa, Jean Dehdashti, Wei Zheng, Christina M. Henderson, Adrian M. Zelazny, Peter R. Williamson   +14 more
doaj   +1 more source

Identification of fungicidal 2,6-disubstituted quinolines with Candida antibiofilm activity

, 2012
We identified two subseries of 2,6-disubstituted quinolines, consisting of 6-amide and 6-urea derivatives, which are characterized by fungicidal activity against Candida albicans with minimal fungicidal concentration (MFC) < 15 μM.
Bardiot, Dorothée, Chaltin, Patrick, Marchand, Arnaud, De Brucker, Katrijn, Cammue, Bruno, Thevissen, Karin, Delattin, Nicolas   +6 more
core  

Molecular Engineering Mediated Interfacial Assembly as an Artificial Extracellular Matrix Remolds Bacteria With Enhanced Abiotic Resilience

Advanced Science, EarlyView.
A biomimetic artificial extracellular matrix is assembled directly on Pseudomonas fluorescens by co‐assembling amyloid‐like lysozyme and alginate at the cell surface. This conformal nanocoating acts as both a hydration buffer and a physiological priming layer, markedly enhancing desiccation tolerance, seed adhesion, storage stability, and biocontrol ...
Yuanyuan Wang, Zili Jia, Yang Li, Qitao Wang, Shuai Hou, Lei Liu   +5 more
wiley   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Can outsourcing pest and disease control help reduce pesticide expenditure? Evidence from rice farmers

Agribusiness, EarlyView.
Abstract Outsourcing pest and disease control (PDC) has grown rapidly worldwide, especially in developing countries. Although numerous studies have investigated various advantages of outsourcing PDC, little is known about its impact on pesticide expenditure.
Pengcheng Wang, Wanglin Ma, Mengling Diao   +2 more
wiley   +1 more source

Antifungal Activity of Copaifera langsdorffii Desf Oleoresin against Dermatophytes

Molecules, 2013
Dermatophytoses are mycoses that affect keratinized tissues in both humans and animals. The aim of this study was to investigate the antifungal activity of the oleoresin extracted from Copaifera langsdorffii Desf.
Nádia R. B. Raposo, Maria das Graças A. M. Chaves, Edilene B. Bolutari, Antônio Márcio R. do Carmo, Hudson C. Polonini, Danielle C. Zimmermam-Franco   +5 more
doaj   +1 more source

Rational Design and Biotechnological Production of Novel AfpB-PAF26 Chimeric Antifungal Proteins

Microorganisms, 2018
Antimicrobial peptides (AMPs) have been proposed as candidates to develop new antimicrobial compounds for medicine, agriculture, and food preservation.
Marcos Heredero, Sandra Garrigues, Mónica Gandía, Jose F. Marcos, Paloma Manzanares   +4 more
doaj   +1 more source

Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin [PDF]

International Journal of Molecular Sciences
Triazoles are compounds with various biological activities, including fungicidal action. They became popular through cholinesterase studies after the successful synthesis of the dual binding femtomolar triazole inhibitor of acetylcholinesterase (AChE, EC 3.1.1.7) by Sharpless et al. via in situ click chemistry.
Dora Kolić, Goran Šinko
openaire   +3 more sources

Antimicrobial Activity of Iberian macroalgae

, 2007
The antibacterial and antifungal activity of 82 marine macroalgae (18 Chlorophyceae, 25 Phaeophyceae and 39 Rhodophyceae) was studied to evaluate their potential for being used as natural preservatives in the cosmetic industry.
Gómez Garreta, Ma. Amelia, Ribera, María Antonia, Lavelli, Luca, Ribera Siguán, María Antonia, Salvador Soler, Noemi, Gómez Garreta, Amelia, Salvador, Noemí   +6 more
core   +1 more source