Results 181 to 190 of about 16,277 (246)
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance
Medicinal Research Reviews, EarlyView.ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi +4 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose To enable MRI‐based nongated 3D depiction of forced expiration with both high spatio‐temporal resolution and fidelity of lung dynamics. Methods An undersampled 3D Fermat looped, orthogonally encoded trajectory (FLORET) was optimized for nonsegmented dynamic acquisitions during forced expiration and a corresponding model‐based ...
Sebastian Scheidel +6 more
wiley +1 more source
Debneyol decoded: A metabolic organizer powers broad‐spectrum plant defense
New Plant Protection, EarlyView.Abstract A new Cell study by Wang et al. resolves the long‐elusive biosynthesis and regulation of debneyol, a fungicidal sesquiterpenoid phytoalexin in Solanaceae. The authors define the complete three‐step route from farnesyl pyrophosphate to debneyol and identify the small protein MCD1 as a metabolic organizer that assembles a multienzyme complex to ...
Shaojie Han
wiley +1 more source
Polymer Engineering &Science, EarlyView.Schematic overview of the preparation and characterization of PLA‐based biocomposites containing mesoporous bioactive glass, highlighting the relationship between particle morphology, composite properties, and their potential for bone regeneration. ABSTRACT The present study proposes the development of a potential biocomposite for bone regeneration by ...
Bruna Segat +5 more
wiley +1 more source
Polymer Engineering &Science, EarlyView.Chitosan dispersions containing biochar derived from vine pruning residue showed increasing shear stress and improved thermal stability with loading. Flow behavior was described by the Bingham plastic model in all cases. These results support the valorization of agricultural waste in functional biopolymer formulations.
Ahmet Eser +3 more
wiley +1 more source