Results 41 to 50 of about 2,362,586 (281)

Constraining Evolution of Alternaria alternata Resistance to a Demethylation Inhibitor (DMI) Fungicide Difenoconazole

Frontiers in Microbiology, 2019
Evolution of fungicide resistance in plant pathogens is one of major concerns in sustainable plant disease management. In this study, the genetics and potential of developing resistance to a demethylation inhibitor (DMI) fungicide, difenoconazole, in the
Meng-Han He, Meng-Han He, Yan-Ping Wang, Yan-Ping Wang, E-Jiao Wu, Lin-Lin Shen, Li-Na Yang, Li-Na Yang, Tian Wang, Li-Ping Shang, Wen Zhu, Jiasui Zhan, Jiasui Zhan, Jiasui Zhan   +13 more
doaj   +1 more source

Governing principles can guide fungicide-resistance management tactics

, 2014
Fungicide-resistance management would be more effective if principles governing the selection of resistant strains could be determined and validated.
Oliver, R., Paveley, N., Oliver, Richard, Bosch, F., Van Den Berg, F., Van Den Bosch, F., Berg, F., Vandenbosch, Frank, Van Den Berg, Femke   +8 more
core   +1 more source

Identification of isolates of the plant pathogen Leptosphaeria maculans with resistance to the triazole fungicide fluquinconazole using a novel In Planta assay. [PDF]

PLoS ONE, 2017
Leptosphaeria maculans is the major pathogen of canola (oilseed rape, Brassica napus) worldwide. In Australia, the use of azole fungicides has contributed to the 50-fold increase in canola production in the last 25 years.
Angela P Van de Wouw, Vicki L Elliott, Steven Chang, Francisco J López-Ruiz, Steven J Marcroft, Alexander Idnurm   +5 more
doaj   +1 more source

Dose-dependent selection drives lineage replacement during the experimental evolution of SDHI fungicide resistance in Zymoseptoria tritici [PDF]

, 2017
Fungicide resistance is a constant threat to agricultural production worldwide. Molecular mechanisms of fungicide resistance have been studied extensively in the wheat pathogen Zymoseptoria tritici.
Michael W. Shaw, Shaw, M. W., Gutierrez-Alonso, O., Hawkins, N. J., Fraaije, B. A., Omar Gutiérrez-Alonso, Gutiérrez-Alonso, O, Nichola J. Hawkins, Bart A. Fraaije, Hans J. Cools, Cools, H. J., Hawkins, Nichola, Fraaije, Bart   +12 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Molecular Mechanisms of Succinate Dehydrogenase Inhibitor Resistance in Phytopathogenic Fungi

Research in Plant Disease, 2020
The succinate dehydrogenase inhibitor (SDHI) is a class of fungicides, which is widely and rapidly used to manage fungal pathogens in the agriculture field.
Hyunkyu Sang, Hyang Burm Lee
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Fungicide Drives De Novo Evolution of Multidrug Resistance in the Plant Growth Promoting Rhizobacterium, Pseudomonas fluorescens

Evolutionary Applications
Soil microbial communities underpin key ecosystem processes, including plant health, nutrient cycling and primary productivity. In agricultural soils, beneficial soil bacteria are often exposed to multiple stressors simultaneously, including fungicides ...
Matthew Kelbrick, James P. J. Hall, Siobhán O'Brien   +2 more
doaj   +1 more source

Sensitivity of Cercospora beticola to fungicides in Slovakia [PDF]

Acta Fytotechnica et Zootechnica, 2020
The fungus Cercospora beticola Sacc. is the one of the most important pathogens on the sugar beet. The frequent application of fungicides with the same mode of action increase a risk of development of resistant strains of the pathogen.
Kamil Hudec, Milan Mihók, Tibor Roháčik, Ľudovít Mišľan   +3 more
doaj   +1 more source