Results 161 to 170 of about 2,598 (200)
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Synthesis of New Furanone Derivatives with Potent Anticancer Activity
Russian Journal of Bioorganic Chemistry, 2020New compounds based on Furanone derivatives were synthesized by reaction of 3-(4-nitrobezylidine)-5-phenylfuran-2(3H)-one with various reagents as malononitrile then D-glucose, thiosemicarbazide then D-glucose, ethyl acetoacetate, acetyl acetone, ethyl cyanoacetate, hydrazine hydrate/acetic acid, thiourea, o-phenylene diamine, hydrazine hydrate/ethanol
W. H. Lashin +3 more
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Chemistry & Biodiversity, 2022
AbstractActinomycetes have being regarded as a treasure reservoir of various bioactive secondary metabolites and devoted many antibiotics in clinicals. Amycolatopsis sp. YNNP 00208 was isolated from a soil sample collected in Gaoligong Mountain area, Yunnan Province, China.
Meng-An, Qian +8 more
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AbstractActinomycetes have being regarded as a treasure reservoir of various bioactive secondary metabolites and devoted many antibiotics in clinicals. Amycolatopsis sp. YNNP 00208 was isolated from a soil sample collected in Gaoligong Mountain area, Yunnan Province, China.
Meng-An, Qian +8 more
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Diverse Pharmacological Potential of Various Furanone Derivatives: A Mini-Review
Mini-Reviews in Organic Chemistry, 2020Abstract:: Furanone is present in many natural compounds. Furanone derivatives are playing important roles in pharmaceutical medicinal and organic chemistry. Various furanone derivatives were exhibited their different pharmacological activities such as antimicrobial, anti-inflammatory, anticancer, antiviral, antioxidant, and other anticipated ...
Asif Husain +3 more
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A New Furanone Isolated from a Marine-Derived Actinomycete M159
Chemistry of Natural Compounds, 2015A new furanone, 5-(4',6'-dihydroxy-6'-methyloctyl)furan-2(5H)-one (1), and a known furanone, 5-(6',7'-dihydroxy-6'-methyloctyl)furan-2(5H)-one (2), were isolated from a marine-derived actinomycete (strain No. M159). The structures of these two compounds were determined on the basis of spectroscopic and chemical data.
Shuju Guo +4 more
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A new synthesis of 5-methylene-2(5H)-furanone derivatives
Tetrahedron, 1984Abstract 5-methylene-2(5H)-furanone derivatives are easily obtained by treatment of tertiary 2-furylcarbinols with pyridinium dichromate in dimethylformamide solution. Through this procedure, a natural product, the thiophene lactone isolated from Chamaemelum Nobile L., has been synthesized.
Antonioletti R +4 more
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Development of Fimbrolides, Halogenated Furanones and their Derivatives as Antimicrobial Agents
2015Traditional treatment for bacterial infection is based on compounds that target bacterial viability or growth. However, a major concern with this approach is the frequent development of drug-resistant mutants. The discovery of bacterial quorum sensing (QS) systems, which control fundamental processes involved in bacterial physiology and virulence, has ...
Kitty K. K. Ho +5 more
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Antifungal 3,5-disubstituted furanones: From 5-acyloxymethyl to 5-alkylidene derivatives
Bioorganic & Medicinal Chemistry, 20105-Acetoxymethyl-3-(4-bromophenyl)-2,5-dihydrofuran-2-one previously described as highly antifungally active was found to provide the corresponding 5-methylene derivative via an unusual DMSO-promoted elimination of the ester group at C5 under antifungal assay conditions.
Petr, Senel +8 more
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The Journal of Physical Chemistry B, 2006
Several 2'-substituted-2'-deoxyribonucleotides are potent inactivators of the enzyme ribonucleotide reductase (RNR), by destroying the essential tyrosyl radical located in subunit R2 or/and covalently alkylating the subunit R1. In the absence of external reductants, the inactivation is achieved by alkylation of subunit R1 by a methylene-3(2H)-furanone.
Nuno M F S A, Cerqueira +2 more
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Several 2'-substituted-2'-deoxyribonucleotides are potent inactivators of the enzyme ribonucleotide reductase (RNR), by destroying the essential tyrosyl radical located in subunit R2 or/and covalently alkylating the subunit R1. In the absence of external reductants, the inactivation is achieved by alkylation of subunit R1 by a methylene-3(2H)-furanone.
Nuno M F S A, Cerqueira +2 more
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[Antifungal activity of 5-benzilidene pyrrolone and furanone derivatives].
Annales pharmaceutiques francaises, 1991The antifungal activity against Neurospora crassa of some 5-benzilidene pyrrolone and furanone derivatives was realised. Relations between the structure and this biological activity are established with Fujita-Ban and Hansch methods. The preponderant part of lipophilicity, resonance effect and E or Z configurations have been showed.
M G, de Carvalho +4 more
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ChemInform Abstract: New Methods for Synthesis of Furanone Derivatives Using Dianions.
Chemischer Informationsdienst, 1984AbstractAusgehend von den Dianionen (III) bzw. (V) bzw. (VIII), deren Herstellung z.Tl. angegeben ist, werden die Furanone (IV) bzw. (VII) bzw. (XI) hergestellt.
K. TANAKA, Y. ISOBE, A. KAJI
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