Results 91 to 100 of about 28,655 (201)

Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases

Neoplasia: An International Journal for Oncology Research, 2013
The proprotein convertases (PCs) furin and PACE4 process numerous substrates involved in tumor growth, invasion, and metastasis. We have previously shown that PCs increase the susceptibility to chemical skin carcinogenesis. Because of the human relevancy
Jian Fu, Daniel E. Bassi, Jirong Zhang, Tianyu Li, Kathy Q. Cai, Courtney Lyons Testa, Emmanuelle Nicolas, Andres J. Klein-Szanto   +7 more
doaj   +1 more source

Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection

Viruses, 2015
Infections by high-risk human papillomaviruses (HPV) are the causative agents for the development of cervical cancer. As with other non-enveloped viruses, HPVs are taken up by the cell through endocytosis following primary attachment to the host cell ...
Linda Cruz, Jennifer Biryukov, Michael J. Conway, Craig Meyers   +3 more
doaj   +1 more source

Functional and Multi-Omics Effects of an Optimized CRISPR-Mediated FURIN Depletion in U937 Monocytes

Cells
The pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and cardiovascular diseases.
Ruiming Chua, Lijin Wang, Roshni Singaraja, Sujoy Ghosh   +3 more
doaj   +1 more source

Furin inhibits HSCs activation and ameliorates liver fibrosis by regulating PTEN‐L/PINK1/parkin mediated mitophagy in mouse

FASEB BioAdvances
Hepatic Stellate cells (HSCs) play an important role during liver fibrosis progression; more and more evidence indicates that mitophagy greatly regulates HSCs activation.
Yan‐Wei Song, Yu‐Hua Zhu, Ming‐Ze Ma   +2 more
doaj   +1 more source

Natural Polymorphisms Are Present in the Furin Cleavage Site of the SARS-CoV-2 Spike Glycoprotein [PDF]

, 2020
Yue Xing, Xiao Li, Xiang Gao, Qunfeng Dong   +3 more
openalex   +1 more source

Influence of organic solvents on the furin activity

The Ukrainian Biochemical Journal, 2018
Furin belongs to a family of calcium-dependent serine proprotein convertases, which transform the inactive protein precursors into mature polypeptides.
T. V. Osadchuk, O. V. Shybyryn, A. V. Semyroz, V. K. Kibirev   +3 more
doaj   +1 more source

A furin-defective cell line is able to process correctly the gp160 of human immunodeficiency virus type 1 [PDF]

, 1994
Yasuo Ohnishi, Tatsuo Shioda, Kazuhisa Nakayama, Shinya Iwata, Bin Gotoh, Michinari Hamaguchi, Yasuhiro Nagai   +6 more
openalex   +1 more source

The dual actions of miRNA16a in restricting Bovine Coronavirus replication through downregulation of Furin and enhancing the host immune response

Scientific Reports
The roles of host cell miRNAs have not been well studied in the context of BCoV replication and immune regulation. This study aimed to identify miRNA candidates that regulate essential host genes involved in BCoV replication, tissue tropism, and immune ...
Abid Ullah Shah, Maged Gomaa Hemida
doaj   +1 more source

Xenon Gas Inhibits the Enzyme Furin In Vitro

, 2020
David Beihl
openalex   +1 more source

Furin-mediated Processing of Pro-C-type Natriuretic Peptide [PDF]

, 2003
Chengliang Wu, Faye Wu, Junliang Pan, John Morser, Qingyu Wu   +4 more
openalex   +1 more source