Results 81 to 90 of about 32,754 (167)

Ribonucleotide reductase subunit M2 mediates the mTOR pathway to recruit furin endoprotease and promote maturation of dengue virus

iScience
Summary: Dengue virus (DENV) maturation involves calcium-dependent endoprotease furin, which cleaves the precursor membrane (prM) into the M protein in the trans-Golgi network, facilitating the release of infectious virus.
Bouchra Kitab, Michinori Kohara, Kyoko Tsukiyama-Kohara   +2 more
doaj   +1 more source

Temporal constraints to major events of the Triassic of the Dolomites (Southern Alps, Italy)

, 2007
Five new U/Pb ages obtained from Triassic ash-fall beds are presented, and preliminary data on other five layers are discussed. Adopting an improved pre-treatment of the samples (Chemical abrasion; Mattinson, 2005) and a standard, highly-precise method ...
FURIN, Stefano
core  

Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics

, 2016
Furin belongs to the family of proprotein convertases (PCs) and is involved in numerous normal physiological and pathogenic processes, such as viral propagation, bacterial toxin activation, cancer, and metastasis.
Robert Day (266252), Manuel E. Than (447895), Sophie Routhier (1291008), Yinghui Lu (576185), Torsten Steinmetzer (1319292), Gero L. Becker (1319289), Frank Sielaff (2064964), Wolfgang Garten (263307), Iris Lindberg (264694)   +8 more
core   +2 more sources

Furin inhibits HSCs activation and ameliorates liver fibrosis by regulating PTEN‐L/PINK1/parkin mediated mitophagy in mouse

FASEB BioAdvances
Hepatic Stellate cells (HSCs) play an important role during liver fibrosis progression; more and more evidence indicates that mitophagy greatly regulates HSCs activation.
Yan‐Wei Song, Yu‐Hua Zhu, Ming‐Ze Ma   +2 more
doaj   +1 more source

Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection

Viruses, 2015
Infections by high-risk human papillomaviruses (HPV) are the causative agents for the development of cervical cancer. As with other non-enveloped viruses, HPVs are taken up by the cell through endocytosis following primary attachment to the host cell ...
Linda Cruz, Jennifer Biryukov, Michael J. Conway, Craig Meyers   +3 more
doaj   +1 more source

Generic turnovers of Carnian/Norian conodonts: climatic control or competition?

, 2009
Pizzo Mondello section (western Sicily, Italy) yields a very rich conodont record, ranging from Late Carnian to Rhaetian in age, shedding new light into the evolution of conodonts across the Carnian/Norian boundary.
M. Mazza, MAZZA M, C. Spötl, RIGO, MANUEL, M. Rigo, FURIN, Stefano, SPOETL C, FURIN S, S. Furin   +8 more
core   +1 more source

Myeloid cell expressed proprotein convertase FURIN attenuates inflammation [PDF]

, 2016
The proprotein convertase enzyme FURIN processes immature pro-proteins into functional end- products. FURIN is upregulated in activated immune cells and it regulates T-cell dependent peripheral tolerance and the Th1/Th2 balance.
S. Aittomäki, I. Junttila, Junttila, Ilkka, Kytölä, Ville, Pesu, Marko, M. Nykter, Grönholm, Anna, Aittomäki, Saara, Hämäläinen, Sanna, Ylipää, Antti, M. Pesu, Z. M. Cordova, A. Ylipää, V. Kytölä, V. Taverniti, Niininen, Vilhelmiina, W. Niininen, A. Grönholm, Cordova, Zuzet Matinn, S. Hämäläinen, Taverniti, Valentina, Nykter, Matti   +21 more
core   +1 more source

Positively Selected Sites at HCMV gB Furin Processing Region and Their Effects in Cleavage Efficiency

Frontiers in Microbiology, 2017
Human cytomegalovirus is a ubiquitous infectious agent that affects mainly immunosuppressed, fetuses, and newborns. The virus has several polymorphic regions, in particular in the envelope glycoproteins.
Lucas M. Stangherlin, Felipe N. de Paula, Felipe N. de Paula, Marcelo Y. Icimoto, Leonardo G. P. Ruiz, Maurício L. Nogueira, Antônio S. K. Braz, Luiz Juliano, Maria C. C. da Silva   +8 more
doaj   +1 more source

Furin processing of integrin αV.

, 2013
The original glioma U251 cells, breast carcinoma MCF-7 cells with the enforced expression of the β3 integrin subunit (MCF7-β3), colon carcinoma LoVo cells with and without the enforced expression of furin and CHO cells with the enforced expression of the
Vladislav S. Golubkov (103758), Eugene Chudin (1365), Sergey A. Shiryaev (103751), Alex Y. Strongin (103770), Piotr Cieplak (103772), Mark S. Chee (103765), Igor A. Kozlov (103768), Andrei V. Chernov (103755), Elliot R. Thomsen (103760)   +8 more
core   +1 more source

Influence of cations on furin activity [PDF]

, 2017
Furin is the most studied proprotein convertase which processes inactive protein precursors, converting them into biologically active polypeptides. We have investigated cation effects of cesium, strontium, cadmium, iron, cobalt and nickel on the furin ...
A. V. Semyroz, O. M. Bondarenko, O. V. Shybyryn, V. K. Kibirev, T. V. Osadchuk   +4 more
core   +2 more sources