Results 91 to 100 of about 32,754 (167)
Maturation of furin substrates and IGF1R signaling are furin activity dependent in RMS cells.
, 2016 A) Maturation of furin substrates upon treatment with pan-PC inhibitor CMK. Rh30 and RD cells were treated with 50 μM CMK for 16h and maturation status of the furin substrates IGF1Rβ, VEGF-C, PDGF-BB and MT1-MMP were examined by immunoblotting. B) IGF1Rβ
Valentina D’Alessandro (1847728) +6 more
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Functional and Multi-Omics Effects of an Optimized CRISPR-Mediated FURIN Depletion in U937 Monocytes
CellsThe pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and cardiovascular diseases.
Ruiming Chua +3 more
doaj +1 more source
Proproteiinikonvertaasi FURIN estää tulehdusta
, 2017 Riittävä muttei ylimitoitettu immuunivaste mahdollisesti haitallisia patogeenejä ja epänormaaleja soluja vastaan on välttämätön, muuten seurauksena voi olla autoimmuunisairauksia, krooninen tulehdus tai syöpä.
Martinez Cordova, Zuzet
core
Synthese, Charakterisierung und Anwendung neuer Inhibitoren der Proproteinkonvertase Furin
, 2014 Die Typ-I Transmembranprotease Furin gehört zur Familie der Proproteinconvertasen und ist ubiquitär im menschlichen Körper verbreitet. Furin aktiviert verschiedenste Proproteine, die sowohl in normalen physiologischen aber auch in zahlreichen ...
Hardes, Kornelia +1 more
core +1 more source
Furin‐Mediated Cleavage of Zona Pellucida Proteins Is Essential for Oocyte Development
MedCommZona pellucida (ZP) proteins, essential for oocyte development, undergo posttranslational regulation through furin‐mediated cleavage. Nevertheless, our understanding of the functional significance of furin‐mediated cleavage of ZP proteins in female ...
Tiechao Ruan +15 more
doaj +1 more source
Novel screening platforms for the identification of inhibitors of the human protease Furin
reservedFurin is a cellular protease that cleaves proteins at polybasic motifs. The processing event modulates the activity of the substrates. So far, a large number of proteins are known to be cleaved by Furin, including some of viral origin.
JORKESH, ALIREZA
core
Endothelial furin and heart development
, 2010 In mammals, seven proprotein convertases (PCs) cleave secretory proteins after basic residues. Four members of this family are called furin-like PCs: furin, PACE4, PC5, and PC7. Furin and PC7 are ubiquitous, while PACE4 and PC5 are widely expressed.
Kim, WooJin
core
Nature CommunicationsReceptor binding of TGF-β and related ligands such as Activin-A requires cleavage of a furin site in their dimeric precursor proteins. Melanoma cells cleave one Activin-A subunit independently of furin and related proprotein convertases, raising ...
Manon Bulliard +5 more
doaj +1 more source
Furin enhances CCHFV propagation.
, 2015 CHO-derived cell lines used were parental clone 6 (Par6), furin-deficient (FD11), and FD11 stably expressing furin (FD11-Fur). Each cell line was infected with CCHFV at multiplicity of infection (MOI) = 1 or with Rift Valley fever virus expressing EGFP ...
Marko Zivcec (191739) +5 more
core +1 more source
Furin is required for the generation of KP from KISS1.
, 2014 A, C. RT-PCR and immunoblot data showing reduced mRNA and protein levels of furin, PCSK5 and PCSK7 in HEK293 cells transduced with shRNA directed against each PC either individually or in combination.
Danny R. Welch (160661) +4 more
core +1 more source