Results 61 to 70 of about 32,754 (167)

GARP does not increase FURIN expression or activity, and does not co-immunoprecipitate with FURIN.

, 2013
A. Expression of FURIN mRNA and protein were analyzed by RT-qPCR and WB in the human cells described in Figure 2. B. FURIN activity was measured 24 hours after transfection of 293 cells.
Bernard Lethé (465016), Caroline Huygens (465015), Pierre G. Coulie (465018), Sophie Lucas (465019), Julie Stockis (465014), Julia Cuende (465013), Jean-François Collet (4693906), Guido Bommer (465017), Emilie Gauthy (465012)   +8 more
core   +1 more source

The possible role furin and furin inhibitors in endometrial adenocarcinoma: A narrative review

Cancer Reports
Background Endometrial adenocarcinoma (EAC) is a malignant tumor of the endometrium. EAC is the most common female malignancy following the menopause period.
Hayder M. Al‐kuraishy, Thabat J. Al‐Maiahy, Ali I. Al‐Gareeb, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El‐Saber Batiha   +6 more
doaj   +1 more source

Integrated Analysis of HER2 Expression and ERBB2 Alterations in Bladder Cancer

Cancer Science, EarlyView.
Integrated analysis of 445 bladder cancers showed that HER2 membrane expression and ERBB2 amplification are distinct features. HER2 expression overlapped with NECTIN4 expression, whereas ERBB2 amplification was enriched in the LumU subtype and associated with poor prognosis.
Kensuke Hirosuna, Kazuki Nishimura, Moritoshi Sakamoto, Satoshi Tokushige, Keita Nakamori, Tomohisa Matsunaga, Yuki Yoshikawa, Takeshi Tsutsumi, Ryoichi Maenosono, Takuya Tsujino, Masahiko Ajiro, Haruhito Azuma, Akihide Yoshimi, Kazumasa Komura   +13 more
wiley   +1 more source

Furin-Catalyzed Enhanced Magnetic Resonance Imaging Probe for Differential Diagnosis of Malignant Breast Cancers

Molecular magnetic resonance imaging (mMRI) of biomarkers is essential for accurate cancer detection in precision medicine. However, the current clinically used contrast agents provide structural magnetic resonance imaging (sMRI) information only and ...
Weiwei Zeng (347272), Zhuoyao Wu (18398623), Yan Xu (14594), Bingbo Zhang (1543171), Weitao Yang (838638)   +4 more
core   +1 more source

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

Analysis of cellular furin.

, 2013
Left panel, Western blotting of total cell furin (15 µg total protein that corresponded to 5-7×104 cells depending on a cell type). Right panel, Western blotting of cell surface-associated furin.
Vladislav S. Golubkov (103758), Mingxing Ouyang (53295), Albert G. Remacle (266254), Sergey A. Shiryaev (103751), Yingxiao Wang (53299), Alex Y. Strongin (103770), Katarzyna Gawlik (266244)   +6 more
core   +1 more source

Functional processing and secretion of Chikungunya virus E1 and E2 glycoproteins in insect cells [PDF]

, 2011
Background: Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has been transmitted to humans in Southern Europe by invading and now established Asian ...
Geertsema, C (Corinne), Corinne Geertsema, van Oers, MM, Paulina Andrade, Heldens, J.G.M., Geertsema, C., Vlak Just M, Pijlman Gorben P, Andrade, Paulina, Vlak, J.M. (Just), Vlak, J.M., Pijlman, G.P. (Gorben), Just M Vlak, Metz Stefan W, Goldbach, RW, Metz, S.W. (Stefan), Martina, B.E.E. (Byron), Geertsema Corinne, Metz, S.W.H., Stefan W Metz, Jacco G Heldens, Geertsema, C. (Corinne), Heldens Jacco G, Martina, Byron, Andrade, P. (Paulina), Metz, SW, Andrade Paulina, Heldens, J., Rob W Goldbach, Pijlman, G.P., Pijlman, GP, van Oers Monique M, Oers, M.M. (Monique) van, van Oers, M.M., Andrade, P, Goldbach, R.W., Gorben P Pijlman, Monique M van Oers, Vlak, JM, Goldbach Rob W, Heldens, JG, Byron E Martina, Martina, Byron E., Martina Byron E, Oers, M.M., van   +44 more
core   +2 more sources

A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C. [PDF]

PLoS ONE, 2009
Furin represents a crucial member of secretory mammalian subtilase, the Proprotein Convertase (PC) or Proprotein Convertase Subtilisin/Kexin (PCSK) superfamily. It has been linked to cancer, tumorgenesis, viral and bacterial pathogenesis.
Ajoy Basak, Abdel-Majid Khatib, Dayani Mohottalage, Sarmistha Basak, Maria Kolajova, Subhendu Sekhar Bag, Amit Basak   +6 more
doaj   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Near-Infrared Fluorescent Furin Probe for Revealing the Role of Furin in Cellular Carcinogenesis and Specific Cancer Imaging

, 2019
Furin, an important member in the family of proprotein convertases, is a participant in the activation of various precursor proteins. The expression level of furin stays in a very low range in most normal cells, but elevates with a big margin in many ...
Longmin Zhu (6920534), Yue Yang (52715), Shuai Xu, Guoliang Ke, Hong-Wen Liu, Ke Li, Xiao-Xiao Hu, Guoliang Ke (1751845), Xiao-Xiao Hu (1473037), Yue Yang, Longmin Zhu, Jun-Bin Li, Ke Li (106849), Hong-Wen Liu (259126), Shuai Xu (147659), Xiao-Bing Zhang, Jun-Bin Li (1413619), Xiao-Bing Zhang (62495)   +17 more
core   +1 more source