Results 121 to 130 of about 42,072 (229)

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Flame retardant biomarker changes with furniture replacement after flammability standard update. [PDF]

Environ Pollut
Attfield KR, Berger K, Dodson RE, Bennett DH, Rodgers KM, Moran R, Stoiber T, Wang Y, Gao S, Smith SC, Park JS, Blum A, Wu N.   +12 more
europepmc   +1 more source

Phosphoryl Radicals from Trivalent Iminyl Phosphines: A Photocatalytic Approach to N‐Phosphoryl Azetidines

Angewandte Chemie, EarlyView.
Photochemically generated phosphoryl radicals from iminyl phosphines enable strain‐release addition to azabicyclobutanes, providing access to elusive N‐phosphoryl azetidines. Combined experimental, computational, and EPR studies reveal an unconventional water‐assisted photoredox pathway.
Chandu G. Krishnan, Gabriel Cormier, Stefano A. Serapian, Marco Bortolus, Luca Dell'Amico   +4 more
wiley   +2 more sources

Automated modeling to high level-of-detail composite object using spatial BIM objects and properties. [PDF]

Sci Rep
Lee JK, Cho D, Kim Y, Mo Y.
europepmc   +1 more source

A need-driven design research of modular functional armchairs for young adults. [PDF]

Sci Rep
Miao Y, Li J, Gao X, Xu W.
europepmc   +1 more source

A practical optimization method for enhancing drilling efficiency in panel furniture manufacture. [PDF]

PLoS One
Wang G, Xiong X, Fu S, Zhang M, Yang L.
europepmc   +1 more source

YOLO-MDEW:Improved YOLOv8 for application of wood board edge banding defect detection. [PDF]

PLoS One
Xiao E, Zhou R, Ruan Z, Chien CJT, Zhu J.   +4 more
europepmc   +1 more source

Difficult to helpful conversations. [PDF]

Can Fam Physician
Allan M.
europepmc   +1 more source

Exploring Smart Furniture: A Systematic Review of Integrated Technologies, Functionalities, and Applications. [PDF]

Sensors (Basel)
Mimoso I, Brites-Pereira M, Alcântara L, Morgado MI, Morgado G, Saavedra I, Muñoz FJM, Louceiro J, Costa E.   +8 more
europepmc   +1 more source

Automated Ergonomic Risk Assessment of Wheelchair Users During Cabinet Interaction Using Vision-Based 3D Pose Estimation. [PDF]

Sensors (Basel)
Xu Y, Yang Z, Sun T, Ning J.
europepmc   +1 more source