Results 131 to 140 of about 76,034 (305)

Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions [PDF]

open access: hybrid, 2020
Hannah Britz   +8 more
openalex   +1 more source

Serendipitous compound action potential oscillations reveal glycolytic astrocyte and oxidative axon interstitial K+ buffering in central white matter

open access: yesExperimental Physiology, EarlyView.
Abstract The principal processes that govern interstitial K+ ([K+]o) buffering in mouse optic nerve (MON), a central white matter tract, either directly consume energy (Na+–K+‐ATPase) or use transmembrane ion gradients created by energy‐dependent pumps to enable the K+ fluxes that maintain a stable [K+]o, and thus ready availability of utilisable ...
Amy J. Hopper, Angus M. Brown
wiley   +1 more source

A Case of Worsened Refractory Ascites due to Prednisolone Administration for Stricture Prevention after Endoscopic Submucosal Dissection for Extensive Early Esophageal Cancer: Case Report and Literature Review

open access: yesDEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Endoscopic submucosal dissection (ESD) is widely used for early esophageal cancer, even in patients with liver cirrhosis (LC). Corticosteroids, administered orally or by local injection, are often used to prevent post‐ESD esophageal stricture. However, their safety in patients with decompensated LC and refractory ascites remains unclear. A man
Yuki Tamura   +9 more
wiley   +1 more source

Machine learning methods for predicting adverse drug events: A systematic review

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 422-444, February 2026.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo   +8 more
wiley   +1 more source

A Case of Drug‐Induced Pancreatitis

open access: yesClinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Drug‐induced pancreatitis (DIP) is a rare but important cause of acute abdominal pain, and ciprofloxacin‐associated cases are exceptionally uncommon. We report a 35‐year‐old woman with no significant medical history who developed severe epigastric pain radiating to the back, accompanied by nausea and vomiting, 3 days after initiating self ...
Muskan Shrestha   +5 more
wiley   +1 more source

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug–Drug Interaction Predictions

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 314-317, February 2026.
Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar   +2 more
wiley   +1 more source

Urinary Kallikrein in normotensive Subjects and in Patients with Essential Hypertension [PDF]

open access: yes, 1980
Distler, A.   +7 more
core   +1 more source

Resistant arterial hypertension in a patient with adrenal incidentaloma multiple steno-obstructive vascular lesions and antiphospholipid syndrome [PDF]

open access: yes, 2015
Resistant hypertension is defined as above of blood pressure (≤ 140/90 mmHg) despite therapy with three or more antihypertensive drugs of different classes at maximum tolerable doses with one bling a diuretic.
CONCISTRE, ANTONIO   +8 more
core  

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