Results 31 to 40 of about 42,923 (283)

Furosemide in pediatric intensive care: a retrospective cohort analysis

Frontiers in Pediatrics
IntroductionFurosemide is the most commonly used medication in pediatric intensive care. Growing data indicates improved hemodynamic stability and efficacy of furosemide infusions compared to intermittent injections, thereby suggesting furosemide ...
Melany Gaetani, Melany Gaetani, Melany Gaetani, Melany Gaetani, Melany Gaetani, Melany Gaetani, Christopher S. Parshuram, Christopher S. Parshuram, Christopher S. Parshuram, Christopher S. Parshuram, Christopher S. Parshuram, Christopher S. Parshuram, Christopher S. Parshuram, Donald A. Redelmeier, Donald A. Redelmeier, Donald A. Redelmeier, Donald A. Redelmeier, Donald A. Redelmeier   +17 more
doaj   +1 more source

Electrochemical Determination of Furosemide Drug at Tranexamic Acid Gold Nanoparticles Modified Glassy Carbon Electrode

Pakistan Journal of Analytical & Environmental Chemistry, 2021
The reported work discussed the simpler and sensitive strategy for the electrochemical determination of furosemide by employed tranexamic acid derived gold nanoparticles modified glassy carbon electrode (GCE).
Tasawar Ali Chandio, Ozcan Yalcinkaya, M. Nasiruddin Khan2, Elif Calik Kayis , Atya Hassan, Ahmet Furkan Kayis   +5 more
doaj   +1 more source

Transfemoral Transcatheter Aortic Valve Implantation (TF‐TAVI) for Patients With Left Ventricular Assist Device (LVAD) and Aortic Regurgitation

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Aortic regurgitation (AR) develops in up to 25%−30% of patients with left ventricular assist device (LVAD). Treatment remains challenging since surgery confers significant peri‐operative risk and the lack of valvular calcification renders transfemoral transcatheter aortic valve implantation (TF‐TAVI) with non‐dedicated devices technically ...
Daniel Tai‐Leung Chan, Ho‐On Alston Conrad Chiu, Ka‐Lam Wong, Ka‐Chun Un, Kwong‐Yue Eric Chan, Shu‐Yue Sze, Chor‐Cheung Frankie Tam, On‐Yat Wong, Gilbert H. L. Tang, Simon Cheung‐Chi Lam   +9 more
wiley   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu, Hui Shen, Jonathan Greenbaum, Qiao‐Rong Yi, Shuang Liang, Yue Zhang, Jia‐Chen Liu, Chuan Qiu, Lan‐Juan Zhao, Qing Tian, Kuan‐Jui Su, Zhe Luo, Li Wu, Xiang‐He Meng, Hong‐Mei Xiao, Yun Deng, Yang Li, Dragana Lovre, Vivian Fonseca, Fernando L. Sanchez, Li‐Jun Tan, Hong‐Wen Deng   +21 more
wiley   +1 more source

Inhaled furosemide for relief of air hunger versus sense of breathing effort: a randomized controlled trial

Respiratory Research, 2018
Background Inhaled furosemide offers a potentially novel treatment for dyspnoea, which may reflect modulation of pulmonary stretch receptor feedback to the brain.
Joanna C. Grogono, Clare Butler, Hooshang Izadi, Shakeeb H. Moosavi   +3 more
doaj   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Association between furosemide administration and outcomes in critically ill patients with acute kidney injury

Critical Care, 2020
Background Although current guidelines for AKI suggested against the use of furosemide in AKI management, the effect of furosemide on outcomes in real-world clinical settings remains uncertain.
Guang-ju Zhao, Chang Xu, Jian-chao Ying, Wen-biao Lü, Guang-liang Hong, Meng-fang Li, Bing Wu, Yong-ming Yao, Zhong-qiu Lu   +8 more
doaj   +1 more source

Effects of Albumin/Furosemide Mixtures on Responses to Furosemide in Hypoalbuminemic Patients [PDF]

Journal of the American Society of Nephrology, 2001
Abstract. Hypoalbuminemic patients often have sufficient fluid accumulation to mandate diuretic therapy but are often resistant to diuresis. Studies have suggested that hypoalbuminemia itself impairs delivery of effective amounts of diuretic agent into the urine, the site of action.
J. Christopher Gorski, Juan F. Maya, Rebecca Craven, John C. Horlander, Naga Chalasani, Helena Hoen, D. Craig Brater   +6 more
openaire   +3 more sources