Results 141 to 150 of about 3,721,647 (391)
Fusion du graphite sous pression d'argon de 1 à 11 500 kg/cm2. Détermination du point triple et établissement d'un diagramme provisoire des états solide, liquide et gazeux du carbone. I [PDF]
, 1939 James Basset
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Condensed Matter Physics, 2004 In the following investigation we pay special attention to the role of self-organization in fusion plasma physics and in the cosmos. We present a new approach to the expansion of the universe. Formally the technique developed relies on our experience from treating hot fusion plasmas.
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Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
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Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
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Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
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Robust Deep Multi-Modal Sensor Fusion using Fusion Weight Regularization and Target Learning
, 2019 Sensor fusion has wide applications in many domains including health care and autonomous systems. While the advent of deep learning has enabled promising multi-modal fusion of high-level features and end-to-end sensor fusion solutions, existing deep ...
Li, Peng +5 more
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I.—Decomposition of camphoric acid by fusion with potash or soda [PDF]
, 1898 Arthur William Crossley, W. H. Perkin
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Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
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A STUDY OF THE SUPERCOOLED FUSIONS AND SOLUTIONS OF SODIUM THIOSULPHATE. [PDF]
, 1904 S. W. Young, J.P. Mitchell
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